PD Dr. Michael Winkler
Infektionsbiologie
Kellnerweg 4
37077 Göttingen
Gesellschaft für Virologie, American Society for Microbiology
2013
Bogdanow B, Weisbach H, von Einem J, Straschewski S, Voigt S, Winkler M, Hagemeier C, Wiebusch L (2013) Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state. PNAS, 110, 17510-17515
Bertram S, Dijkman R, Habjan M, Heurich A, Gierer S, Glowacka I, Welsch K, Winkler M, Schneider H, Hofmann-Winkler H, Thiel V, Pöhlmann S (2013) TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium. J. Virol., 87, 6150-6160
Gierer S, Bertram S, Kaup F, Wrensch F, Heurich A, Krämer-Kühl A, Welsch K, Winkler M, Meyer B, Drosten C, Dittmer U, von Hahn T, Simmons G, Hofmann H, Pöhlmann S (2013) The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies. J. Virol., 87, 5502-11
2012
Sinigalia E, Alvisi G, Segré CV, Mercorelli B, Muratore G, Winkler M, Hsiao HH, Urlaub H, Ripalti A, Chiocca S, Palù G, Loregian A (2012) The human cytomegalovirus DNA polymerase processivity factor UL44 is modified by SUMO in a DNA-dependent manner. PLoS One, 7, e49630
Winkler M, Bertram S, Gnirß K, Nehlmeier I, Gawanbacht A, Kirchhoff F, Ehrhardt C, Ludwig S, Kiene M, Moldenhauer AS, Goedecke U, Karsten CB, Kühl A, Pöhlmann S (2012) Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells. PLoS One, 7, e43337
Müller D, Schreiner S, Schmid M, Groitl P, Winkler M, Dobner T (2012) Functional cooperation between human adenovirus type 5 early region 4, open reading frame 6 protein, and cellular homeobox protein HoxB7. J. Virol., 86, 8296-8308
2010
Fertey J, Ammermann I, Winkler M, Stöger R, Iftner T, Stubenrauch F (2010) Interaction of the papillomavirus E8--E2C protein with the cellular CHD6 protein contributes to transcriptional repression. J. Virol., 84, 9505-9515
Straschewski S, Warmer M, Frascaroli G, Hohenberg H, Mertens T, Winkler M (2010) Human Cytomegaloviruses Expressing Yellow Fluorescent Fusion Proteins - Characterization and Use in Antiviral Screening. PLoS ONE, 5, e9174
Kuenzel S, Till A, Winkler M, Häsler R, Lipinski S, Jung S, Grötzinger J, Fickenscher H, Schreiber S, Rosenstiel P (2010): The Nucleotide Oligomerization Binding Domain-Like Receptor NLRC5 Is Involved in IFN-Dependent Antiviral Immune Responses. J. Immunol., 184, 1990 -2000
2009
Liu Z, Winkler M, Biegalke B (2009) Human cytomegalovirus: host immune modulation by the viral US3 gene. Int J Biochem Cell Biol., 41, 503-506
2008
Dal Pozzo F, Andrei G, Daelemans D, Winkler M, Piette J, De Clercq E, Snoeck R (2008) Fluorescence-based antiviral assay for the evaluation of compounds against vaccinia virus, varicella zoster virus and human cytomegalovirus. J Virol Methods, 151, 66-73
2006
Reinhardt B, Winkler M, Schaarschmidt P, Pretsch R, Lüske A, Vaida B, Schmid-Kotsas A, Michel D, Walther P, Bachem M, Mertens T (2006) HCMV-induced reduction of extracellular matrix proteins in vascular smooth muscle cell cultures: a pathomechanism in vasculopathies? J. Gen. Virol., 87, 2849-2858
2005
Oswald F, Winkler M, Cao Y, Astrahantseff K, Soizic Bourteele S, Knöchel W, Borggrefe T (2005) RBP-Jκ-SHARP recruit corepressors CtIP-CtBP to silence Notch target genes. Mol. Cell. Biol., 25, 10379-10390
Schierling K, Buser C, Mertens T, Winkler M (2005) The Human Cytomegalovirus tegument protein pUL35 is important for viral replication and particle formation. J. Virol, 79, 3084-3096
2004
Schierling K, Stamminger T, Mertens T, Winkler M (2004) The Human Cytomegalovirus tegument proteins ppUL82(pp71) and ppUL35 interact and co-operatively activate the major immediate-early enhancer. J Virol, 78, 9512-9523
2003
Shen C, Buck AK, Liu X, Winkler M, Reske SN (2003) Gene silencing by adenovirus-delivered siRNA. FEBS Lett, 539, 111-114
Lischka P, Sorg G, Kann M, Winkler M, Stamminger T (2003) A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. J Virol. 77, 3734-3748
Winkler M (2003) Interactions and Functions of Human Cytomegalovirus Tegument Proteins. Monogr Virol., 24, 113–121
2002
Stamminger T, Gstaiger M, Weinzierl K, Lorz K, Winkler M, Schaffner W (2002) The open reading frame UL26 of human cytomegalovirus encodes a novel tegumant protein that contains a strong transcriptional activation domain. J Virol, 76, 4836-4847
2001
Fernandez LA, Winkler M, Grosschedl R (2001) Matrix attachment region-dependent function of the immunoglobulin m enhancer involves histone acetylation at a distance without changes in enhancer occupancy. Mol Cell Biol, 21, 196-208
2000
Winkler M, aus dem Siepen T, Stamminger T (2000) Functional interaction between pleiotropic transactivator pUL69 of human cytomegalovirus and the human homolog of yeast chromatin regulatory protein SPT6. J Virol, 74, 8053-8064
1998
Fernandez LA, Winkler M, Forrester W, Jenuwein T, Grosschedl R (1998) Nuclear matrix attachment regions confer long-range function upon the immunoglobulin μ enhancer. Cold Spring Harb Symp Quant Biol, 63, 515-524
1996
Winkler M, Stamminger T (1996) A specific subform of the human cytomegalovirus transactivator protein pUL69 is contained within the tegument of virus particles. J Virol, 70, 8984-8987
1995
Winkler M, Schmolke S, Plachter B, Stamminger T (1995) The pUL69 Protein of Human Cytomegalovirus (HCMV), a Homologue of the Herpes Simplex Virus ICP27, is Contained within the Tegument of Virions and Activates the Major Immediate-early Enhancer of HCMV in Synergy with the Tegument Protein pp71 (ppUL82). Scand J Infect Dis Suppl, 99, 8-9
1994
Winkler M, Rice SA, Stamminger T (1994) UL69 of human cytomegalovirus, an open reading frame with homology to ICP27 of herpes simplex virus, encodes a transactivator of gene expression. J Virol, 68, 3943-3954