DPZ-Hauptseite
Menü mobile menu

Prof. Dr. Stefan Pöhlmann

Leitung

Infektionsbiologie

+49 551 3851-150

+49 551 3851-184

SPoehlmann(at)dpz.eu

B 3.12

Kellnerweg 4
37077 Göttingen

Originalarbeiten

Kirchhoff, F., S. Pöhlmann, M. Hamacher, R.E. Means, T. Kraus, K. Überla and P.D. Marzio. Simian Immunodeficiency Virus Variants with Differential T-cell and Macrophage Tropism Use CCR5 and an Unidentified Cofactor Expressed in CEMx174 Cells for Efficient Entry. J. Virol., 1997 71(9): 6509-16. IF:4.7

Pöhlmann, S., S. Flöss, P.O. Ilyinskii, T. Stamminger and F. Kirchhoff. Sequences just upstream of the simian immunodeficiency virus core enhancer allow efficient replication in the absence of NF-kappaB and Sp1 binding elements. J. Virol., 1998 72(7): 5589-98. IF:4.7

Pöhlmann, S., M. Krumbiegel and F. Kirchhoff. Coreceptor usage of BOB/GPR15 and Bonzo/STRL33 by primary isolates of human immunodeficiency virus type 1. J. Gen. Virol., 1999 80(Pt 5): 1241-51. IF: 2.8

Pöhlmann, S., N. Stolte, J. Münch, P. Ten Haaft, J.L. Heeney, C. Stahl-Hennig and F. Kirchhoff. Co-receptor usage of BOB/GPR15 in addition to CCR5 has no significant effect on replication of simian immunodeficiency virus in vivo. J. Infect. Dis., 1999 180(5): 1494-502. IF: 6.3

Pöhlmann, S., B. Lee, S. Meister, M. Krumbiegel, G. Leslie, R.W. Doms and F. Kirchhoff. Simian immunodeficiency virus utilizes human and sooty mangabey but not rhesus macaque STRL33 for efficient entry. J. Virol., 2000 74(11): 5075-82. IF:4.7

Sharron, M., S. Pöhlmann, K. Price, E. Lolis, M. Tsang, F. Kirchhoff, R.W. Doms and B. Lee. Expression and coreceptor activity of STRL33/Bonzo on primary peripheral blood lymphocytes. Blood, 2000 96(1): 41-9. IF: 13.2

Detheux, M., L. Ständker, J. Vakili, J. Münch, U. Forssmann, K. Adermann, S. Pöhlmann, G. Vassart, F. Kirchhoff, M. Parmentier and W.G. Forssmann. Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties. J. Exp. Med., 2000 192(10): 1501-8. IF: 11.9

Pöhlmann, S., E.J. Soilleux, F. Baribaud, G.J. Leslie, L.S. Morris, J. Trowsdale, B. Lee, N. Coleman and R.W. Doms. DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and immunodeficiency viruses and activates infection in trans. Proc. Natl. Acad. Sci. USA, 2001 98(5): p. 2670-5. IF: 9.2

Pöhlmann, S., F. Baribaud, B. Lee, G.J. Leslie, M.D. Sanchez, K. Hiebenthal-Millow, J. Münch, F. Kirchhoff and R.W. Doms. DC-SIGN interactions with human immunodeficiency virus type 1, type 2 and simian immunodeficiency virus. J. Virol., 2001 75(10): 4664-72. IF:4.7

Meister, S., C. Otto, A. Papkalla, M. Krumbiegel, S. Pöhlmann and F. Kirchhoff. Basic Amino Acid Residues in the V3 Loop of Simian Immunodeficiency Virus Envelope Alter Viral Coreceptor Tropism and Infectivity but Do Not Allow Efficient Utilization of CXCR4 as Entry Cofactor. Virology, 2001 284(2):  287-96. IF: 3.4

Baribaud, F., S. Pöhlmann, T. Sparwasser, M.T.Y. Kimata, Y.-K. Choi, B.S. Haggarty, N. Ahmad, T. Macfarlan, T. Edwards, G.J. Leslie, J. Arnason, T.A. Reinhart, J.T. Kimata, D.R. Littman, J.A. Hoxie and R.W. Doms. Functional and Antigenic Characterization of human, rhesus macaque, pigtail macaque, and murine DC-SIGN. J. Virol., 2001 75(21): 10281-9. IF:4.7

Pöhlmann, S., G.J. Leslie, T. Edwards, T. Macfarlan, J.D. Reeves, K. Hiebenthal-Millow, F. Kirchhoff, F. Baribaud and R.W. Doms. DC-SIGN Interactions with Human Immunodeficiency Virus: Virus-Binding and Transfer are dissociable Functions. J. Virol., 2001 75(21): 10523-6. IF:4.7

Soilleux, E.J., L.S. Morris, B. Lee, S. Pöhlmann, J. Trowsdale, R.W. Doms and N. Coleman. Placental Expression of DC-SIGN may mediate Intrauterine Vertical Transmission of HIV. J. Pathol., 2001 195: 586-92. IF: 6.9

Jameson, B., F. Baribaud, S. Pöhlmann, D. Ghavimi, F. Mortari, R.W.Doms and A. Iwasaki. Expression of DC-SIGN by intestinal and genital mucosal dendritic cells in humans and rhesus macaques. J. Virol. 2002 76(4): p.1866-75.       IF:4.7

Puffer, B.A., S. Pöhlmann, M.D. Sanchez, J. Reitter, H. Fox, R.C. Desrosiers, and R.W. Doms. Relationship between CD4-independence, viral tropism, pathogenicity, and neutralization sensitivity in SIV Env. J. Virol., 2002 76(6): 2595-605. IF:4.7

Münch, J., L. Ständker, S. Pöhlmann, F. Baribaud, A. Papkalla, O. Rosorius, R. Stauber, G. Sass, N. Heveker, K. Adermann, E. Klüver, R.W. Doms, W.-G. Forssmann and F. Kirchhoff. Human CC chemokine 1 [9-74] induces CCR5 internalization and inhibits replication of R5-tropic HIV isolates in primary T-cells and macrophages. Antimicrob. Agents Chemother. 2002 46(4):982-990. IF: 4.3

Baribaud, F., S. Pöhlmann, G. Leslie, F. Mortari and R.W. Doms. Quantitative expressionand virus transmission analysis of DC-SIGN on monocyte-derived dendritic cells. J. Virol. 2002 Sep;76(18): 9135-42. IF:4.7

Turville, S.G., P.U. Cameron, A. Handley, G. Lin, S. Pöhlmann, R.W. Doms and A.L. Cunningham. Diversity of receptors binding HIV on dendritic cell subsets. Nat. Immunol. 2002 3(10): 975-83. IF: 21.5

Reeves, J.D., S.A. Gallo, N. Ahmad, J. Miamidian, P. Harvey, M. Sharron, S. Pöhlmann, J.N. Sfakianos, C.A. Derdyn, R. Blumenthal, E. Hunter and R.W. Doms. Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics. Proc. Natl. Acad. Sci. USA, 2002 99(25): 16249-54. IF: 9.2

Lin, G., G. Simmons, S. Pöhlmann, F. Baribaud, H. Ni, G.J. Leslie, B.S. Haggartey, P. Bates, D. Weissman, J.A. Hoxie and R.W. Doms. Differential N-Linked Glycoslylation of HIV and Ebola Virus Envelope Glycoproteins Modulates Interactions with DC-SIGN and DC-SIGNR. J. Virol. 2003 77: 1337-46 IF:4.7

Simmons, G., J.D. Reeves, C.C. Grogan, L.H. Vandenberghe, F. Baribaud, R.C. Netter, J.L. Riley, R.W. Doms, P. Bates and S. Pöhlmann. DC-SIGN and DC-SIGNR bind Ebola glycoproteins and enhance infection of macrophages and endothelial cells. Virology. 2003. 305: 115-23. IF: 3.4

Pöhlmann, S., J. Zhang, F. Baribaud, Z. Chen, G. Lin, A. Granelli-Piperno, R.W. Doms, C.M. Rice, and J.A. Keating. Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR. J.Virol. 2003 77(7):4070-80 IF:4.7

Otto, C., B. Puffer, S. Pöhlmann, R.W. Doms and F. Kirchhoff. Mutations in the C3 Region of Human and Simian Immunodeficiency Virus Envelope have Differential Effects and Viral Infectivity, Replication and CD4-Dependency. Virology. 2003. 315(2): 292-302. IF: 3.4

Pöhlmann, S., C. Davis, S. Meister, G.J. Leslie, C. Otto, J.D. Reeves, B.A. Puffer, A. Papkalla, M. M. Krumbiegel, A. Marzi, S. Lorenz, J. Münch, R.W. Doms and F. Kirchhoff. Amino acid 324 in the simian immunodeficiency virus V3 loop can confer CD4 independence and modulate the interaction with CCR5 and alternative coreceptors. J. Virol. 2004. 78(7):3223-32. IF:4.7

Hofmann, H., K. Hattermann, A. Marzi, T. Gramberg, M. Geier, M. Krumbiegel, S. Kuate, K. Überla, M. Niedrig, and S. Pöhlmann. The S protein of the severe acute respiratory syndrome (SARS) associated coronavirus mediates entry into hepatocytes and is targeted by neutralizing antibodies in infected patients. J.Virol. 2004 78(12):6134-42. IF:4.7

Hiebenthal-Millow, K., S. Pöhlmann, J. Münch and F. Kirchhoff. Differential Regulation of Human Immunodeficiency Virus Type 2 and Simian Immunodeficiency Virus Promoter Activity. Virology 2004 324(2):501-9 IF: 3.4

Hofmann, H., M. Geier, A. Marzi, M. Krumbiegel, M. Peipp, G.H. Fey and S. Pöhlmann. Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor. Biochem. Biophys. Res. Commun. 2004  319(4): 1216-1221319. IF: 2.5

Marzi, A., T. Gramberg, G. Simmons, M. Krumbiegel, M. Geier, B. Saunier, P. Bates, H. Hofmann and S. Pöhlmann. DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome associated coronavirus. J. Virol. 2004 78(21):12090-5. IF:4.7

Hofmann, H., K. Pyrc, L. van der Hoek, M. Geier, B. Berkhout and S. Pöhlmann. Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry. Proc. Natl. Acad. Sci. U S A. 2005 102(22):7988-93. IF: 9.2

Gramberg, T., H. Hofmann, P. Möller, A. Marzi, M. Geier, M. Krumbiegel, T. Winkler, F. Kirchhoff, S. Becker, J. Münch and S. Pöhlmann. LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus. Virology 2005 340(2):224-36. IF: 3.4

Suzuki-Inoue, K., G.L. Fuller, A. Garcia, J.A. Eble, S. Pöhlmann, O. Inoue, T.K. Gartner, S.C. Hughan, A.C. Pearce, G.D. Laing, R.D. Theakston, E. Schweighoffer, N. Zitzmann, T. Morita, V.L. Tybulewcz, Y. Ozaki and S. P. Watson. A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood 2006 107(2):542-9. IF: 13.2

Gramberg, T., I. Caminschi, A. Wegele, H. Hofmann and S. Pöhlmann. Evidence that multiple defects in murine DC-SIGN inhibit a functional interaction with pathogens. Virology 2006 345(2):482-91. IF: 3.4

Gramberg, T., T. Zhu, C. Chaipan, A. Marzi, H. Liu, A. Wegele, T. Andrus, H. Hofmann and S. Pöhlmann. Impact of polymorphisms in the DC-SIGNR neck domain on the interaction with pathogens. Virology 2006 347(2):354-63 IF: 3.4

Caminschi, I., K. M. Lucas, M. Sofi, D. Vremec, T. Gramberg, S. Pöhlmann, Ken Shortman and M. D. Wright. The mouse dendritic cell C-type lectin CIRE/mouseDC-SIGN differs in ligand specificity from human DC-SIGN. Int. Immunol. 2006 18(5):741-53. IF : 3.7

Marzi, A., A. Akhavan, G. Simmons, T. Gramberg, H. Hofmann, P. Bates, V. R. Lingappa, and S. Pöhlmann. The signal peptide of the Ebolavirus glycoprotein influences the interaction with the cellular lectins DC-SIGN and DC-SIGNR. J. Virol. 2006 80(13):6305-17. IF:4.7

Hofmann, H., G. Simmons, A. J. Rennekamp, C. Chaipan, T. Gramberg,  E. Heck, M. Geier, A. Wegele, A. Marzi, P. Bates, and S. Pöhlmann. Highly conserved regions within the spike proteins of human coronaviruses 229E and NL63 determine recognition of their respective cellular receptors. J. Virol. 2006 80(17):8639-52 IF:4.7

Chaipan, C., E. J. Soilleux, P. Simpson, H. Hofmann, T. Gramberg, A. Marzi, M. Geier, E. A. Stewart, J. Eisemann, A. Steinkasserer, K. Suzuki-Inoue, G. L. Fuller, A. C. Pearce, S. P. Watson, J. A. Hoxie, F. Baribaud, and S. Pöhlmann. DC-SIGN and CLEC-2 mediate HIV-1 capture by platelets. J. Virol. 2006 80(18):8951-60 IF:4.7

Marzi, A., A. Wegele and S. Pöhlmann. Modulation of virion incorporation of Ebolavirus glycoprotein: Effects on attachment, cellular entry and neutralization. Virology 2006 352(2):345-56 IF: 3.4

Marzi, A., P. Möller, S.L. Hanna, T. Harrer, J. Eisemann, A. Steinkasserer, S. Becker, F. Baribaud and S. Pöhlmann. Analysis of the interaction between Ebolavirus glycoprotein and DC-SIGN and DC-SIGNR. J. Infect. Dis. 2007 Suppl 2:S237-46 IF: 6.3

 Pöhlmann S., J. Münch, S. Aziz, J.D. Reeves, C. Otto, G.J. Leslie, H. Hofmann, B.A. Puffer, F. Baribaud, A. Marzi, T. Gramberg, Z. Chen, N. Stolte, P.T. Haaft, J.L. Heeney, C. Stahl-Hennig, K. Matz-Rensing, T. Schneider, R.W. Doms and F. Kirchhoff. A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo. Virology 2007 360(2):275-85 IF: 3.4

Münch, J., L. Ständker, K. Adermann, A. Schulz, M. Schindler, R. Chinnadurai, S. Pöhlmann, C. Chaipan, T. Biet,  T. Peters, B. Meyer, D. Wilhelm, H. Lu, W. Jing, S. Jiang , W.G. Forssmann and F. Kirchhoff. Discovery and optimization of a natural HIV-1 entry inhibitor  targeting the gp41 fusion peptide. Cell 2007 129(2):263-75. IF : 30.4

Fuller, G.L., J.A. Williams, M.G. Tomlinson, J.A. Eble, S.L. Hanna, S. Pöhlmann, K. Suzuki-Inoue, Y. Ozaki, S.P. Watson and A.C. Pearce. The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signalling cascade.
J Biol Chem. 2007 282(17):12397-409. IF: 4.1

Marzi, A., D.A. Mitchell, C. Chaipan, T. Fisch, R.W. Doms, M. Carrington,  R.C. Desrosiers, S. Pöhlmann. Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin. Virology 2007 368(2):322-30. IF: 3.4

Powlesland, A.S., T. Fisch, M.E. Taylor, D.F. Smith, B. Tissot, A. Dell, S. Pöhlmann, K. Drickamer. A novel mechanism for LSECtin binding to Ebola virus surface glycoprotein through truncated glycans. J. Biol. Chem. 2008 283(1):593-602 IF: 4.1

Gramberg, T., E.J. Soilleux, T. Fisch, P.F.Lalor, H. Hofmann, S. Wheeldon, A. Cotterill, A. Wegele, T. Winkler, D.H. Adams and S. Pöhlmann. Interactions of LSECtin and DC-SIGN/DC-SIGNR with viral ligands: Differential pH-dependence, internalization and virion binding. Virology 2008 373(1):189-201 IF: 3.4

Chaipan C, D. Kobasa, S. Bertram, I. Glowacka, I. Steffen, T. Solomon Tsegaye, M. Takeda, T. Bugge, S. Kim, Y. Park, A. Marzi and S. Pöhlmann. Proteolytic activation of the 1918 influenza virus hemagglutinin. J. Virol. 2009 83(7):3200-11 IF:4.7

Glowacka I., S. Bertram, P. Herzog, S. Pfefferle, I. Steffen, F. Weber, J. Eichler, C. Drosten and S. Pöhlmann. Differential downregulation of ACE2 by the spike proteins of SARS-coronavirus and human coronavirus NL63. J. Virol. 2010 84(2):1198-205 IF:4.7

Kühl, A., J. Münch, D. Sauter, S. Bertram, I. Glowacka, I. Steffen, A. Specht, H. Hofmann, H. Schneider, G. Behrens and S. Pöhlmann. Calcium-modulating cyclophilin ligand does not restrict retrovirus release. Nat Med. 2010 16(2):155-6 IF: 29.9

Chaipan, C., I. Steffen, T. Solomon-Tsegaye, S. Bertram, I. Glowacka, Y. Kato, J. Schmökel, J. Münch, R. Gerardy-Schahn and S. Pöhlmann. Incorporation of podoplanin into human immunodeficiency virus particles mediates binding to the attachment factor CLEC-2 and transmission to target cells. Retrovirology 2010 May 19;7:47 IF: 3.9

Zhou Y., K. Lu, S. Pfefferle, S. Bertram, I. Glowacka, C. Drosten, S. Pöhlmann and G. Simmons. A Single Asparagine-Linked Glycosylation Site of the SARS-Coronavirus Spike Glycoprotein Facilitates Inhibition by Mannose-Binding Lectin through Multiple Mechanisms. J. Virol. 2010 84(17):8753-64. IF:4.7

Bertram S., I. Glowacka, P. Blazejewska, E. Soilleux, P. Allen, S. Danisch, I. Steffen, S.-Y. Choi, Y. Park, H. Schneider, K. Schughart, and S. Pöhlmann. TMPRSS2 and TMPRSS4 facilitate trypsin-independent influenza virus spread in Caco-2 cells. J. Virol. 84:10016-25. IF:4.7

Glowacka I., S. Bertram, M. A. Müller, P. Allen, E. Soilleux, S. Pfefferle, I. Steffen, T.S. Tsegaye, Y. He, K. Gnirss, D. Niemeyer, H. Schneider, C. Drosten, and S. Pöhlmann. Evidence that TMPRSS2 activates the SARS-coronavirus spike-protein for membrane fusion and reduces viral control by the humoral immune response. J. Virol. 2011 85:4122-34 IF:4.7

Simmons G, S. Bertram, I. Glowacka, I. Steffen, C. Chaipan, J. Agudelo, K. Lu, A.J. Rennekamp, H. Hofmann, P. Bates and S. Pöhlmann. Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion. Virology. 2011 413(2):265-74. IF: 3.4

Kühl A, M. Hoffmann,  M.A. Müller, V.J. Munster, K. Gnirß, M. Kiene, T. Solomon Tsegaye, G. Behrens, G. Herrler, H. Feldmann, C. Drosten, and S. Pöhlmann. Comparative analysis 1 of Ebola virus glycoprotein interactions with human and bat cells. J. Infect. Dis., 2011, 204 Suppl 3:S840-9 IF = 6.3

Kühl A., C. Banning,  A. Marzi, J. Votteler, I. Steffen, S. Bertram,  I. Glowacka,  A. Konrad, M. Stürzl, J.-T. Guo, U. Schubert,  H. Feldmann, G. Behrens, M. Schindler and S. Pöhlmann. The Ebola virus glycoprotein and HIV-1 Vpu employ 1 different strategies to    counteract the antiviral factor tetherin. J. Infect. Dis., 2011, 204, Suppl. 3 S850-60

Pipirou Z., A.S. Powlesland, I. Steffen, S. Pöhlmann, M.E. Taylor and K. Drickamer. Mouse LSECtin as a model for a human Ebola virus receptor. Glycobiology. 2011 21(6):806-12 IF: 3.1

Pfefferle S, J. Schöpf, M. Kögl, C.C. Friedel, M.A. Müller, J. Carbajo-Lozoya, T. Stellberger, E. von Dall'Armi, P. Herzog, S. Kallies, D. Niemeyer, V. Ditt, T. Kuri, R. Züst, K. Pumpor, R. Hilgenfeld, F. Schwarz, R. Zimmer, I. Steffen, F. Weber, V. Thiel, G. Herrler, H.J. Thiel, C. Schwegmann-Wessels, S. Pöhlmann, J. Haas, C. Drosten, A and von Brunn. The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors. PLoS Pathog. 2011 Oct;7(10):e1002331. IF : 6.6

Bertram S ., I. Glowacka, M.A. Müller, H. Lavender, K. Gnirß, I. Nehlmeier, D. Niemeyer, Y. He,  G. Simmons, C. Drosten, E.J. Soilleux, O. Jahn, I. Steffen  and S. Pöhlmann. Cleavage and activation of the SARS-coronavirus spike-protein by human airway trypsin-like protease (HAT). J. Virol. 2011 85(24):13363-72. IF:4.7

Pritschet, K., N. Donhauser, P. Schuster, M. Ries, S. Haupt, N.A. Kittan, K. Korn, S. Pöhlmann, G. Holland, N. Bannert, E. Bogner and B. Schmidt. CD4- and dynamin-dependent endocytosis of HIV-1 into plasmacytoid dendritic cells. Virology. 2012 423(2):152-64. IF: 3.4

Gnirß, K., A. Kühl, C. Karsten, I. Glowacka, S. Bertram, F. Kaup, H. Hofmann and  S. Pöhlmann. Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression. Virology. 2012 424(1):3-10. IF: 3.4

Bertram S., A. Heurich, H. Lavender, S. Gierer, S. Danisch, P. Perin, J.M. Lucas, P.S. Nelson, S. Pöhlmann and E.J. Soilleux. Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts. PLoS One. 2012;7(4):e35876. IF: 2.8

Winkler M., S. Bertram, K. Gnirß, I. Nehlmeier, A. Gawanbacht, F. Kirchhoff, C. Ehrhardt, S. Ludwig, M. Kiene, A.S. Moldenhauer, U. Goedecke, C.B. Karsten, A. Kühl and S. Pöhlmann. Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells. PLoS One. 2012;7(8):e43337. IF: 2.8

Kiene M., A. Marzi, A. Urbanczyk, S. Bertram, T. Fisch, I. Nehlmeier, K. Gnirss, C.B. Karsten, D. Palesch, J. Münch, F. Chiodi and S. Pöhlmann, I. Steffen. The role of the alternative coreceptor GPR15 in SIV tropism for human cells.Virology. 2012 433(1):73-84. IF: 3.4

Hofmann H., X. Li, X. Zhang, W. Liu, A. Kühl, F. Kaup, S.S. Soldan , F. González-Scarano, F. Weber, Y. He and S. Pöhlmann. Severe Fever with Thrombocytopenia Virus Glycoproteins Are Targeted by Neutralizing Antibodies and Can Use DC-SIGN as a Receptor for pH-Dependent Entry into Human and Animal Cell Lines.J. Virol. 2013 87(8):4384-94. IF:4.7

Solomon Tsegaye T., K. Gnirß, N. Rahe-Meyer, M. Kiene, A. Krämer-Kühl, G. Behrens, J. Münch, S. Pöhlmann. Platelet activation suppresses HIV-1 infection of T cells. Retrovirology 2013 10:48. IF: 3.9

Gierer S., S. Bertram, F. Kaup, F. Wrensch, A. Heurich, A. Krämer-Kühl, K. Welsch, M. Winkler, B. Meyer, C. Drosten, U. Dittmer, T. von Hahn, G. Simmons, H. Hofmann and S. Pöhlmann. The spike-protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2 and is targeted by neutralizing antibodies. J. Virol. 2013 87(10):5502-11 IF:4.7

Bertram S, R. Dijkman, M. Habjan, A. Heurich, S. Gierer, I. Glowacka, K. Welsch, M. Winkler, H. Schneider, H. Hofmann-Winkler, V. Thiel and S. Pöhlmann. TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium. J. Virol. 2013 87(11):6150-60 IF:4.7

Gierer S, H. Hofmann-Winkler, W.H. Albuali, S. Bertram, A.M. Al-Rubaish, A.A. Yousef, A.N. Al-Nafaie, A.K. Al-Ali, O.E. Obeid, K.R. Alkharsah, S. Pöhlmann. Lack of MERS coronavirus neutralizing antibodies in humans, eastern province, Saudi Arabia. Emerg Infect Dis. 2013 Dec;19(12):2034-6. IF : 8.2

Hatesuer B., S. Bertram, N. Mehnert, M.M. Bahgat, P.S. Nelson, S. Pöhlmann, K. Schughart. Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice. PLoS Pathog. 2013 Dec;9(12):e1003774. IF : 6.6

Heurich A., H. Hofmann-Winkler, S. Gierer, T. Liepold, O. Jahn, S. Pöhlmann. TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein. J. Virol. 2014 Jan;88(2):1293-307. IF:4.7

Kiene M., B. Rethi, M. Jansson, S. Dillon, E. Lee, R. Lantto, C. Wilson, S. Pöhlmann, F. Chiodi. Toll-like receptor 3 signalling up-regulates expression of the HIV co-receptor G-protein coupled receptor 15 on human CD4+ T cells. PLoS One 2014 Feb 18;9(2):e88195. IF: 2.8

Gnirß K., M. Fiedler, A. Krämer-Kühl, S. Bolduan, E. Mittler, S. Becker, M. Schindler, S. Pöhlmann. Analysis of determinants in filovirus glycoproteins required for tetherin antagonism. Viruses. 2014 Apr 9;6(4):1654-71. IF: 3.5

Eckert N., F. Wrensch, S. Gärtner, N. Palanisamy, U. Goedecke, N. Jäger, S. Pöhlmann, M. Winkler. Influenza a virus encoding secreted gaussia luciferase as useful tool to analyze viral replication and its inhibition by antiviral compounds and cellular proteins. PLoS One. 2014 May 19;9(5):e97695. IF: 2.8

Gehring G., K. Rohrmann, N. Atenchong, E. Mittler, S. Becker, F. Dahlmann, S. Pöhlmann, F.W. Vondran, S. David, M.P. Manns, S. Ciesek, T. von Hahn. The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry. J Antimicrob Chemother. 2014 69(8):2123-31 IF: 4.3

Wrensch F., M. Winkler and S. Pöhlmann. IFITM proteins inhibit entry driven by the MERS-coronavirus spike protein: evidence for cholesterol-independent mechanisms. Viruses. 2014 6(9):3683-98. IF: 3.5

Zmora P., P. Blazejewska, A.S. Moldenhauer, K. Welsch, I. Nehlmeier, Q. Wu, H. Schneider, S. Pöhlmann, S. Bertram. DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry. J. Virol. 2014 88(20):12087-97. IF:4.7

Gierer S, M.A. Müller, A. Heurich, D. Ritz, B.L. Springstein, C.B. Karsten, A. Schendzielorz, K. Gnirß, C. Drosten C, and S. Pöhlmann. Inhibition of Proprotein Convertases Abrogates Processing of the Middle Eastern Respiratory Syndrome Coronavirus Spike Protein in Infected Cells but Does Not Reduce Viral Infectivity. J Infect Dis. 2014. 211(6):889-97 IF: 6.3

Hofmann-Winkler H., K. Gnirß, F. Wrensch and S. Pöhlmann. Comparative Analysis of Host Cell Entry of Ebola Virus From Sierra Leone, 2014, and Zaire, 1976. J Infect Dis. 2015, 212 Suppl 2 : S172-80.

Dahlmann F, N. Biedenkopf, A. Babler, W. Jahnen-Dechent, C.B. Karsten, K. Gnirß, H. Schneider, F. Wrensch, C.A. O'Callaghan, S. Bertram, G. Herrler, S. Becker, S. Pöhlmann and H. Hofmann-Winkler. Analysis of Ebola Virus Entry Into Macrophages. J Infect Dis. 2015; 212 Suppl 2 : S247-57

Wrensch F., C.B. Karsten, K. Gnirß, M. Hoffmann, K. Lu, A. Takada, M. Winkler, G. Simmons and S. Pöhlmann. Interferon-Induced Transmembrane Protein-Mediated Inhibition of Host Cell Entry of Ebolaviruses. J Infect Dis. 2015, 212  Suppl. 2: S210-8.

Zhou Y., P. Vedantham, K. Lu, J. Agudelo, R. Carrion Jr., J.W. Nunneley, D. Barnard, S. Pöhlmann, J.H. McKerrow, A.R. Renslo, G. Simmons G. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Res. 2015 Apr;116:76-84. IF : 4.3

Gnirß K., P. Zmora, P. Blazejewska, M. Winkler, A. Lins, I. Nehlmeier, S. Gärtner, A.S. Moldenhauer, H. Hofmann-Winkler, T. Wolff, M. Schindler and S. Pöhlmann. Tetherin Sensitivity of Influenza A Viruses Is Strain Specific: Role of Hemagglutinin and Neuraminidase. J. Virol. 2015 89(18):9178-88. IF:4.7

Zmora P., A.S. Moldenhauer, H. Hofmann-Winkler and S. Pöhlmann. TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells. PLoS One 2015 10(9):e0138380. IF: 2.8

Karsten C.B., F.F. Buettner, S. Cajic, I. Nehlmeier, B. Neumann, A. Klippert, U. Sauermann, U. Reichl, R. Gerardy-Schahn, E. Rapp, C. Stahl-Hennig and S. Pöhlmann. Exclusive Decoration of Simian Immunodeficiency Virus Env with High-Mannose Type N-Glycans Is Not Compatible with Mucosal Transmission in Rhesus Macaques. J. Virol. 2015 89(22):11727-33. IF:4.7

Hoffmann M., M. González Hernández, E. Berger, A. Marzi, and S. Pöhlmann. The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent. PLoS One 2016 11(2):e0149651. IF: 2.8

Hoffmann M., N. Krüger, P. Zmora , F. Wrensch, G. Herrler, S. Pöhlmann. The Hemagglutinin of Bat-Associated Influenza Viruses Is Activated by TMPRSS2 for pH-Dependent Entry into Bat but Not Human Cells. PLoS One 2016 11(3):e0152134. IF: 2.8

Guo Y., C. Sakonsinsiri, I. Nehlmeier, M.A. Fascione, H. Zhang, W. Wang, S. Pöhlmann, W.B. Turnbull, and D. Zhou. Compact, Polyvalent Mannose Quantum Dots as Sensitive, Ratiometric FRET Probes for Multivalent Protein-Ligand Interactions. Angew Chem Int Ed Engl. 2016 55(15):4738-42. IF : 12.0

Kühn N., S. Bergmann, N. Kösterke, R.L. Lambertz, A. Keppner, J.M. van den Brand, S. Pöhlmann, S. Weiß, E. Hummler, B. Hatesuer, and K. Schughart. The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases. J. Virol. 2016 90(9):4298-307. IF:4.7

Plegge T., H. Hofmann-Winkler, M. Spiegel, and S. Pöhlmann. Evidence that Processing of the Severe Fever with Thrombocytopenia Syndrome Virus Gn/Gc Polyprotein Is Critical for Viral Infectivity and Requires an Internal Gc Signal Peptide. PLoS One. 2016 11(11):e0166013. IF: 2.8

Brinkmann C., I. Nehlmeier, K. Walendy-Gnirß, J. Nehls, M. González Hernández, M. Hoffmann, X. Qiu, A. Takada, M. Schindler and S. Pöhlmann. The Tetherin Antagonism of the Ebola Virus Glycoprotein Requires an Intact Receptor-Binding Domain and Can Be Blocked by GP1-Specific Antibodies. J. Virol. 2016 90(24):11075-11086. IF:4.7

Wrensch F., M. Hoffmann, S. Gärtner, I. Nehlmeier, M. Winkler, and S. Pöhlmann. Virion background and efficiency of virion incorporation determine susceptibility of SIV-Env-driven viral entry to inhibition by IFITM proteins. J. Virol. 2017 J. Virol., Jan 3;91(2)

Zmora P., P. Molau-Blazejewska, S. Bertram, K. Walendy-Gnirß, I. Nehlmeier, A. Hartleib, AS. Moldenhauer, S. Konzok, S. Dehmel, K. Sewald, C. Brinkmann, C. Curths, S. Knauf, J. Gruber, K. Mätz-Rensing, F. Dahlmann, A. Braun, and S. Pöhlmann. Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin. PLoS One 2017 11;12(5). IF: 2.8

Winkler M., S. Gärtner, F. Wrensch, M. Krawczak, U. Sauermann, and S. Pöhlmann. Rhesus macaque IFITM3 gene polymorphisms and SIV infection. PLoS One 2017 3;12(3):e0172847. IF: 2.8

Pöhlmann S., M. Suntz, V. Akimkin, M. Bleyer, and A. Kaul. Herpes B virus replication and viral lesions in the liver of a cynomolgus macaque which died from severe disease with rapid onset. J Med Primatol. 2017 doi: 10.1111/jmp.12269. IF : 0.8

Hoffmann M., L. Crone, E. Dietzel, J. Paijo, M. González-Hernández, I. Nehlmeier, U. Kalinke, S. Becker, and S. Pöhlmann. A Polymorphism within the Internal Fusion Loop of the Ebola Virus Glycoprotein Modulates Host Cell Entry. J. Virol. 2017 13;91(9).  IF:4.7

Wrensch F., M. Hoffmann, S. Gärtner, I. Nehlmeier, M. Winkler, and S. Pöhlmann. Virion Background and Efficiency of Virion Incorporation Determine Susceptibility of Simian Immunodeficiency Virus Env-Driven Viral Entry to Inhibition by IFITM Proteins. J. Virol. 2017 3;91(2). pii: e01488-16. IF:4.7

Gerlach T., L. Hensen, T. Matrosovich, J. Bergmann, M. Winkler, C. Peteranderl, HD. Klenk, F. Weber, S. Herold, S. Pöhlmann, and M. Matrosovich. pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs. J. Virol. 2017 12;91(11). IF:4.7

Pöhlmann S., A. Krüger, W. Hafezi, S. Schneider, J. Gruber, M. Winkler, and A. Kaul. Detection systems for antibody responses against herpes B virus. Primate Biol. 2017 4, 9-16. No IF

Guo Y., I. Nehlmeier, E. Poole, C. Sakonsinsiri, N. Hondow, A. Brown, Q. Li, S. Li, J. Whitworth, Z. Li, A. Yu, R. Brydson, W.B. Turnbull, S. Pöhlmann, and D. Zhou. Dissecting Multivalent Lectin-Carbohydrate Recognition Using Polyvalent Multifunctional Glycan-Quantum Dots. J Am Chem Soc. 2017 doi: 10.1021/jacs.7b05104. IF : 13.9

Reinke L.M., M. Spiegel, T. Plegge, A. Hartleib, I. Nehlmeier, S. Gierer, M. Hoffmann, H.   Hofmann-Winkler, M. Winkler, and S. Pöhlmann. Different residues in the SARS-CoV spike  protein determine cleavage and activation by the host cell protease TMPRSS2. PLoS One 2017 Jun 21;12(6):e0179177. doi: 10.1371 IF: 2.8
 
 

Übersichtsartikel (peer-review, n =16)
 

Baribaud, F., S. Pöhlmann and R.W. Doms. The Role of DC-SIGN and DC-SIGNR in HIV and SIV attachment, infection and transmission. Virology, 2001 286(1): 1-6. IF: 3.4

Pöhlmann, S., F. Baribaud and R.W. Doms. DC-SIGN and DC-SIGNR: Helping hands for HIV. Trends Immunol., 2001 22(12): 643-645. IF: 13.3

Pöhlmann, S. and R.W. Doms. Closing the door on HIV: Evaluation of current strategies to inhibit viral entry. Current Drug Targets-Infectious Disorders, 2002 2(1), 9-16.

Baribaud, F., R.W. Doms and S. Pöhlmann. The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination? Expert Opin. Ther. Targets. 2002 6(4): 423-32. IF:4.8

Pierson, T.C., R.W. Doms and S. Pöhlmann. Prospects of HIV-1 entry inhibitors as novel therapeutics. Rev. Med. Virol. 2004 14(4): 255-70. IF: 5.4

Pöhlmann, S. and J.D. Reeves. Cellular entry of HIV: Evaluation of therapeutic targets. Cur. Pharm. Des. 2006 12(16): 1963-1973. IF: 2.6

Hofmann, H. and S. Pöhlmann. Cellular entry of the SARS coronavirus. Trends Microbiol. 2004 12(10):466-72 IF: 11.0

Choi, S.Y., S. Bertram, I. Glowacka, Y. Park and S. Pöhlmann. Type II transmembrane serine proteases in cancer and viral infections. Trends Mol. Med. 2009 15(7):303-12 IF: 10.7

Steffen, I. and S. Pöhlmann. Peptide-based inhibitors of the HIV envelope protein and other class I viral fusion proteins. Curr. Pharm. Des. 2010;16(9):1143-58 IF: 2.6

Bertram, S., I. Glowacka, I. Steffen, A. Kühl, and S. Pöhlmann. Novel insights into proteolytic cleavage of influenza virus hemagglutinin. Rev. Med. Virol., 2010 20(5):298-310 IF: 5.4

Solomon-Tsegaye T. and S. Pöhlmann. The multiple facets of HIV attachment to dendritic cell lectins. Cell Microbiol. 2010 12(11):1553-61 IF: 4.6

Hofmann-Winkler H., F. Kaup and S. Pöhlmann. Host cell factors in filovirus entry: novel players, new insights. Viruses. 2012 4(12):3336-62 . IF: 3.5

Kühl A. and S. Pöhlmann. How ebola virus counters the interferon system. Zoonoses Public Health. 2012 Sep; 59 Suppl 2:116-31.

Simmons G., P. Zmora, S. Gierer, A. Heurich, S. Pöhlmann. Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research. Antiviral Res. 2013 Dec;100(3):605-14. IF : 4.3

Van Breedam W., S. Pöhlmann, H.W. Favoreel, R.J. de Groot, H.J. Nauwynck HJ. Bitter-sweet symphony: glycan-lectin interactions in virus biology. FEMS Microbiol Rev. 2014, 38(4):598-632. IF: 12.2

Spiegel M., T. Plegge, and S. Pöhlmann. The Role of Phlebovirus Glycoproteins in Viral Entry, Assembly and Release. Viruses. 2016 8(7). pii: E202. IF: 3.5


Buchkapitel und andere Publikationen
 

Pöhlmann, S., T. Gramberg, A. Wegele, K. Pyrc, L. van der Hoek, B. Berkhout and H. Hofmann. Interaction between the spike protein of human coronavirus NL63 and its cellular receptor ACE2. Adv. Exp. Med. Biol. Sci. 2006 581:281-4

Hofmann, H., A. Marzi, T. Gramberg, M. Geier, K. Pyrc, L. van der Hoek, B. Berkhout and S. Pöhlmann. Attachment factor and receptor engagement of SARS coronavirus and human coronavirus NL63. Adv. Exp. Med. Biol. Sci. 2006 581:219-27

Reeves, J.D., S.D. Barr and S. Pöhlmann. Evaluation of current strategies to inhibit HIV-1 entry, integration and maturation. Bogner, E.  and  A. Holzenburg (eds). New concepts of antiviral Therapies. Springer, New York, Dodrecht, 2006, ISBN 0-387-31046-0

Pöhlmann, S. Interaction of hemorrhagic fever viruses with dendritic cells. In Handbook of Dendritic Cells: Biology, Diseases and Therapies. Lutz  M. Romani N. and Steinkasserer A. (Eds.) 2006, ISBN 3-527-31109-2 - Wiley-VCH, Weinheim.

Pöhlmann S, and M. Tremblay. Attachment of human immunodeficiency virus to cells and its inhibition. In Entry Inhibitors in HIV Therapy. J.D. Reeves and C.A. Derdeyn (Eds.) 2007, ISBN 978-3-7643-7782-3.

Pöhlmann, S. Carbohydrates on HIV: mediators of immune evasion and targets for antiviralintervention. Future HIV Therapy, 2008, 2(3): 253-257.

Steffen I., T. Solomon-Tsegaye, S. Pöhlmann. Lectin-like interactions in virus-cell recognition:human immunodeficiency virus and C-type lectin interactions. In Microbial Glycobiology: Structures, Relevance and Applications. A. Moran, P. Brennan, O. Holst and M. von Itzstein (Eds.) 2009, Chapter 28

Glowacka, I., S. Bertram, S. Pöhlmann. Cellular entry of the SARS-coronavirus: Implications for transmission, pathogenicity and antiviral strategies. In Molecular Biology of the SARS coronavirus. S. Lal (Ed.) S. Lal (Ed.) Springer, 2010, 3-22.

Hofmann, H. and S. Pöhlmann. DC-SIGN: Access Portal for Sweet Viral Killers. Cell Host Microbe. 2011, 10(1):5-7.

Lindemann D., I. Steffen I, S. Pöhlmann. Cellular entry of retroviruses. Adv Exp Med Biol. 2013;790:128-49.

Karsten C., Pöhlmann S., Encyclopedia of AIDS, 2014, Hope, T.J., M. Stevenson, D. Richman, Chapter on Attachment/Binding. http://dx.doi.org/10.1007/978-1-4614-9610-6_61-1. Springer New York

 

 

 

 

https://www.researchgate.net/profile/Stefan_Poehlmann2

https://orcid.org/0000-0001-6086-9136

http://www.researcherid.com/rid/H-2395-2011

https://www.linkedin.com/in/stefan-p%C3%B6hlmann-74971296/

https://publons.com/a/1357213

Zurück zur Übersicht