The Platform Infection Models focuses on the functional characterization of viruses, the testing of antiviral drugs and vaccines, as well as the investigation of the immune response following vaccination or infection. In order to investigate specific issues related to infectious diseases, suitable infection models are established and continuously developed.
Publications
- Richel E, Cordsmeier A, Bauer L, Fraedrich K, Vestweber R, Roshani B, Stolte-Leeb N, Ensser A, Stahl-Hennig C, Überla K.
Mechanisms of sterilizing immunity provided by an HIV-1 neutralizing antibody against mucosal infection.
PLoS Pathog. 2024 Dec 26;20(12):e1012777. - DOI - - Hasan MZ, Claus M, Krüger N, Reusing S, Gall E, Bade-Döding C, Braun A, Watzl C, Uhrberg M, Walter L
SARS-CoV-2 infection induces adaptive NK cell responses by spike protein-mediated induction of HLA-E expression.
Emerg Microbes Infect. 2024 Dec;13(1):2361019 - DOI - - Zhang L, Cheng HH, Krüger N, Hörnich B, Graichen L, Hahn AS, Schulz SR, Jäck HM, Stankov MV, Behrens GMN, Müller MA, Drosten C, Mörer O, Winkler MS, Qian Z, Pöhlmann S, Hoffmann M
ACE2-independent sarbecovirus cell entry can be supported by TMPRSS2-related enzymes and can reduce sensitivity to antibody-mediated neutralization.
PLoS Pathog. 2024 Nov 13;20(11):e1012653. - DOI - - Oneto A, Hamwi GA, Schäkel L, Krüger N, Sylvester K, Petry M, Shamleh RA, Pillaiyar T, Claff T, Schiedel AC, Sträter N, Gütschow M, Müller CE
Nonpeptidic Irreversible Inhibitors of SARS-CoV-2 Main Protease with Potent Antiviral Activity.
J Med Chem. 2024 Sep 12;67(17):14986-15011 - DOI -
The Platform Infection Models is engaged in teaching at University of Veterinary Medicine Hannover.
Courses of the current semester