The Platform Infection Models focuses on the functional characterization of viruses, the testing of antiviral drugs and vaccines, as well as the investigation of the immune response following vaccination or infection. In order to investigate specific issues related to infectious diseases, suitable infection models are established and continuously developed.
Publications
- Krüger N, Laufer SA, Pillaiyar T
An overview of progress in human metapneumovirus (hMPV) research: Structure, function, and therapeutic opportunities
Drug Discov Today. 2025 Apr 24. doi:10.1016/j.drudis.2025.104364 - DOI - - Jebran AF, Seidler T, Tiburcy M, Daskalaki M, Kutschka I, Fujita B, Ensminger S, Bremmer F, Moussavi A, Yang H, Qin X, Mißbach S, Drummer C, Baraki H, Boretius S, Hasenauer C, Nette T, Kowallick J, Ritter CO, Lotz J, Didié M, Mietsch M, Meyer T, Kensah G, Krüger D, Sakib MS, Kaurani L, Fischer A, Dressel R, Rodriguez-Polo I, Stauske M, Diecke S, Maetz-Rensing K, Gruber-Dujardin E, Bleyer M, Petersen B, Roos C, Zhang L, Walter L, Kaulfuß S, Yigit G, Wollnik B, Levent E, Roshani B, Stahl-Henning C, Ströbel P, Legler T, Riggert J, Hellenkamp K, Voigt JU, Hasenfuß G, Hinkel R, Wu JC, Behr R, Zimmermann WH
Engineered heart muscle allografts for heart repair in primates and humans.
Nature. 2025 Jan 29. doi: 10.1038/s41586-024-08463-0 - DOI - - Flury P, Krüger N, Sylvester K, Breidenbach J, Al Hamwi G, Qiao J, Chen Y, Rocha C, Serafim MSM, Barbosa da Silva E, Pöhlmann S, Poso A, Kronenberger T, Rox K, O'Donoghue AJ, Yang S, Sträter N, Gütschow M, Laufer SA, Müller CE, Pillaiyar T
Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV‑2 Main Protease and Its Variants Displaying Potent Antiviral Activity.
J Med Chem. 2025 Jan 15. doi: 10.1021/acs.jmedchem.4c02254. - DOI - - Richel E, Cordsmeier A, Bauer L, Fraedrich K, Vestweber R, Roshani B, Stolte-Leeb N, Ensser A, Stahl-Hennig C, Überla K.
Mechanisms of sterilizing immunity provided by an HIV-1 neutralizing antibody against mucosal infection.
PLoS Pathog. 2024 Dec 26;20(12):e1012777. - DOI -
The Platform Infection Models is engaged in teaching at University of Veterinary Medicine Hannover.
Courses of the current semester