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Peer-reviewed publications

  1. Huttner, W.B., Heide, M., Mora-Bermudez, F. and Namba, T. (2024) Neocortical neurogenesis in development and evolution–Human-specific features. J. Comp. Neurol. 1-11. https://doi.org/10.1002/cne.25576
  2. Eşiyok, N. and Heide, M. (2023). The SVZ stem cell niche–components, functions and in vitro modelling. Front. Cell Dev. Biol. 11, 1332901. https://doi.org/10.3389/fcell.2023.1332901
  3. Heide, M. and Huttner W.B. (2023). Causes of microcephaly in human–theoretical considerations. Front. Neurosci. 17, 1306166. https://doi.org/10.3389/fnins.2023.1306166
  4. Tynianskaia, L., Eşiyok, N., Huttner, W. B., Heide, M. (2023). Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification. J. Vis. Exp. (193), e65176 https://doi.org/10.3791/65176
  5. Fischer, J., Fernandez Ortuno E., Marsoner, F., Artioli, A., Peters, J., Namba, T., Eugster Oegema, C., Huttner, W.B.*, Ladewig, J.* and Heide, M.* (2022). Human-specific ARHGAP11B ensures human-like basal progenitor levels in hominid cerebral organoids. EMBO Rep., e54728. *joint corresponding authors https://doi.org/10.15252/embr.202254728
  6. Di Donato, N., Guerrini, R., Billington, C.R., Barkovich, J., Dinkel, P., Freri, E., Heide, M., Gershon, G.S., Gertler, T.S., Hopkin, R.J., Jacob, S., Keedy, S.K., Kooshavar, D., Lockhart, P.J., Lohmann, D.R., Mahmoud, I.G., Parrini, E., Schrock, E., Severi, G., Timms, A.E., Webster, R.I., Willis, M.J.H., Zaki, M.S., Gleeson, J.G., Leventer, R.J. and Dobyns, W.B. (2022). Monoallelic and biallelic mutations in RELN underlie a graded series of neurodevelopmental disorders, Brain, awac164 https://doi.org/10.1093/brain/awac164
  7. Heide, M.* and Huttner W.B.* (2021). Human-specific genes, cortical progenitor cells, and microcephaly. Cells 10, 1209-1215. *joint corresponding authors https://doi.org/10.3390/cells10051209
  8. Heide, M.*, Haffner, C., Murayama, A., Kurotaki, Y., Shinohara, H., Okano H., Sasaki, E. and Huttner W.B.* (2020). Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset. Science 369, 546-550. *joint corresponding authors https://doi.org/10.1126/science.abb2401
  9. Fischer, J.*, Heide, M.*# and Huttner, W.B.# (2019). Genetic modification of brain organoids. Front Cell Neurosci 13, 558. *joint first authors, #joint corresponding authors https://doi.org/10.3389/fncel.2019.00558
  10. Kanton, S., Boyle, M.J., He, Z., Santel, M., Weigert, A., Calleja, F.S., Guijarro, P., Sidow, L., Fleck, J.S., Han, D., Qian, Z., Heide, M., Huttner, W.B., Khaitovich, P., Pääbo, S., Treutlein, B. and Camp, J.G. (2019). Organoid single-cell genomic atlas uncovers human-specific features of brain development. Nature 574, 418-422. https://doi.org/10.1038/s41586-019-1654-9
  11. Heide, M., Huttner, W.B. and Mora-Bermudez, F. (2018). Brain organoids as models to study human neocortex development and evolution. Curr Opin Cell Biol 55, 8-16. https://doi.org/10.1016/j.ceb.2018.06.006
  12. Florio, M.*, Heide, M.*, Pinson A., Brandl, H., Albert, M., Winkler, S., Wimberger, P., Huttner, W.B. and Hiller, M. (2018). Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex. eLife 7:e32332. *joint first authors https://doi.org/10.7554/eLife.32332
  13. Heide, M., Long, K.R. and Huttner, W.B. (2017). Novel gene function and regulation in neocortex expansion. Curr Opin Cell Biol 49, 22-30. https://doi.org/10.1016/j.ceb.2017.11.008
  14. Boothe, T., Hilbert, L., Heide, M., Berninger, L., Huttner, W.B., Zaburdaev, V., Vastenhouw, N.L., Myers, E.W., Drechsel, D.N. and Rink, J.C. (2017) A tunable refractive index matching medium for live imaging cells, tissues and model organisms. eLife 6:e27240. https://doi.org/10.7554/eLife.27240
  15. Miquelajáuregui, A., Sandoval-Schaefer, T., Martínez-Armenta, M., Pérez-Martínez, L., Cárabez, A., Zhao, Y., Heide, M., Alvarez-Bolado, G., Varela-Echavarría, A. (2015). LIM homeobox protein 5 (Lhx5) is essential for mamillary body development. Front Neuroanat 9, 136. https://doi.org/10.3389/fnana.2015.00136
  16. Heide, M., Zhang, Y., Zhou, X., Zhao, T., Miquelajáuregui, A., Varela-Echavarría, A., Alvarez-Bolado, G. (2015). Lhx5 controls mamillary differentiation in the developing hypothalamus of the mouse. Front Neuroanat 9, 113. https://doi.org/10.3389/fnana.2015.00113
  17. Haddad-Tóvolli, R., Heide, M., Zhou, X., Blaess, S., Alvarez-Bolado, G. (2012). Mouse thalamic differentiation: gli-dependent pattern and gli-independent prepattern. Front Neurosci 6, 27. https://doi.org/10.3389/fnins.2012.00027

Non peer-reviewed publication

  1. Heide, M.* and Huttner W.B.* (2023). Wie menschenspezifische Gene den Primaten-Neokortex vergrößerten. BIUZ 3/2023 (53) *joint corresponding authors https://doi.org/10.11576/biuz-6543
  2. Eşiyok, N., Tynianskaia, L. and Heide M. (2023). Primatenspezifische Gene als Determinanten der Neokortexmorphologie. Biospektrum 02/23 S.130-133. https://doi.org/10.1007/s12268-023-1903-1
  3. Heide, M.* and Huttner W.B.* (2020). Grundlagen und Mechanismen der Neocortex-Expansion. Biospektrum 04/20 S.393-397 *joint corresponding authors https://doi.org/10.1007/s12268-020-1411-5
  4. Heide, M., Florio, M., Huttner, W.B. (2016). Die Rolle humanspezifischer Gene in der Gehirnentwicklung und -evolution. Biospektrum 04/16 S.352-355