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Mitarbeiter

Dr. Fazal Wahab

Gastwissenschaftler

Degenerative Erkrankungen

+49 551 3851-323

FWahab(at)dpz.eu

Kellnerweg 4
37077 Göttingen

Research Fellow

Kisspeptin-Kiss1r and GnIH-GPR147 signaling pathways role in the regulation of puberty and adult reproductive function in primates.

  1. Wahab F, Santos-Junior NN, Rodrigues RPA, Costa LHA, Catalão CHR, Rocha MJA. Interleukin-1 Receptor Antagonist decreases hypothalamus oxidative stress during experimental sepsis. Molecular Neurobiology; In Press
  2. Shamas S,  Khan SH,  Khan MY, Shabbir N, Zubair H, Shafqat S, Wahab F, Shahab M: Fasting induced kisspeptin signaling suppression is regulated by glutamate mediated cues in adult male rhesus macaque (Macaca mulatta). Neuropeptides: In press, doi:10.1016/j.npep.2015.06.005
  3. Wahab F, Drummer C, Behr R. Marmoset Monkeys. Current Biology, In press
  4. Wahab F, Shahab M, Behr R.The involvement of gonadotropin inhibitory hormone and kisspeptin in the metabolic regulation of reproduction. J Endocrinol. 2015 May;225(2):R49-R66.
  1. Ramzan MH, Ramzan M, Ramzan F, Wahab F, Jelani M, Khan MA, Shah M. Insight into the serum kisspeptin levels in infertile males.Arch Iran Med. 2015 Jan;18(1):12-7. doi: 0151801/AIM.005. http://www.ams.ac.ir/AIM/NEWPUB/15/18/1/005.pdf 
  2.   Human semen quality and sperm DNA damage assessed by comet assay in clinical groups Ramzan Ha, Ramzan M, Khan MM, Ramzan F, Wahab F, Aslam Khan MA, Jillani M, Shah M Turkish Journal of Medical Sciences 05/2015; 45(3):729-737.
  3. Wahab F, Tazinafo LF, Cárnio EC, Aguila FA, Batalhão ME, Rocha MJA. (2014): Interleukin-1 receptor antagonist decreases cerebrospinal fluid nitric oxide levels and increases vasopressin secretion in the late phase of sepsis in rats. Endocrine, 1-7
  4. Batool A, Naz R, Wazir M, Azam A, Ullah R, Wahab F, Shahab M. (2014): Acute Fasting-Induced Repression of the Hypothalamic-Pituitary-Gonadal Axis is Reversed by RF-9 Administration in the Adult Male Macaque. Hormone and Metabolic Research. 
  5. Wahab F, Atika B, Huma T, Shahab M. (2014): Primate HPT Axis Response to the Peripheral Kisspeptin Challenge Under Different Time Periods of Food Restriction in Monkeys. Hormone and metabolic research. 2014 Mar;46(3):187-92. http://dx.doi.org/10.1055/s-0033-1363263
  6. Wahab F, Atika B, Oliveira-Pelegrin GR, Rocha MJA. (2014): Recent Advances in the Understanding of Sepsis-Induced Alterations in the Neuroendocrine System. Endocrine, Metabolic & Immune Disorders-Drug Targets. 13(4):335-47
  7. Wahab, F., Atika, B., Shahab, M. (2013): Kisspeptin as a link between Metabolism and Reproduction: Evidences from Rodents and Primates Studies. Metabolism; http://dx.doi.org/10.1016/j.metabol.2013.01.015
  8. Irfan S, Ehmcke J, Wahab F, Shahab M, Schlatt S. (2013): Intratesticular action of kisspeptin in rhesus monkey (Macaca mulatta). Andrologia. http://dx.doi.org/10.1111/and.12121     
  9. Wahab, F., Zaman, U., Shahab, M. (2012): Differential response of the primate HPG axis to N-methyl-D, L- aspartate but not to kisspeptin challenge under euglycemic and hypoglycemic condition. Hormone and Metabolic Research 44(06), 451-457. http://dx.doi.org/10.1055/s-0032-1306309 
  10. Wahab, F., Salahuddin, H., Anees, M., Wiqar, M.A., Hashim, R., Leprince, J., Vaudry, H., Tena-Sempere, M., Shahab, M. (2012): Study of the effect of 26RF- and 43RF-amides on testosterone and prolactin secretion in the adult male rhesus monkey (Macaca mulatta). Peptides 36(1), Pages 23–28. http://dx.doi.org/10.1016/j.peptides.2012.04.009 
  11. Qaiser, F., Wahab, F., Wiqar, M.A., Hashim, R., Leprince, J., Vaudry, H., Tena-Sempere, M., Shahab, M. (2012): Role of the evolutionary conserved 26 RF- and 43 RF- amides neuropeptides in the growth hormone release in the adult male rhesus monkey (Macaca mulatta). Endocrine 42(3), 658-663. http://dx.doi.org/10.1007/s12020-012-9672-5 
  12. Wahab, F., Riaz, T., Khan, L.A., Shahab, M. (2012): Peripheral administration of the human kisspeptin-10 inhibits the reproductive axis in the adult male broiler breeder birds (Gallus domesticus).  Pakistan Journal of Zoology 44(1):7-14. http://zsp.com.pk/pdf44/7-14 _2_ PJZ-494-10 Wahab F-MS.pdf 
  13. Chan, Y.M., Broder-Fingert, S., Paraschos, S., Lapatto, R., Au, M,, Hughes, V., Bianco, S.D.C., Min, L., Plummer, L., Cerrato, F., Guillebon, A.D., Wu, I.H., Wahab, F., Dwyer, A., Kirsch, S., Quinton, R., Cheetham, T., Ozata, M., Ten, S., Chanoine, J.P., Pitteloud, N., Crowley, W.F.Jr., Martin, K.A., Schiffmann, R., Kamp, H.J.V., Hall, J.E., Kaiser, U.B., Seminara, S.B. (2011): GnRH-Deficient Phenotypes in Humans and Mice with Heterozygous Mutations in KISS1/Kiss1. Journal of Clinical Endocrinology and Metabolism 96(11), E1771-81. http://dx.doi.org/10.1210/jc.2011-0518 
  14. Wahab, F., Quinton, R., Seminara, S.B. (2011): The kisspeptin signaling pathway and its role in human isolated GnRH deficiency. Molecular and Cellular Endocrinology 346(1-2), 29-36. http://dx.doi.org/10.1016/j.mce.2011.05.043 
  15. Wahab, F., Ullah, F., Chan, Y.M., Seminara, S.B., Shahab, M. (2011): Decrease in hypothalamic Kiss1 and Kiss1r expression: a potential mechanism for fasting-induced suppression of the HPG axis in the adult male rhesus monkey (Macaca mulatta). Hormone and Metabolic Research 43(2), 81-85. http://dx.doi.org/10.1055/s-0030-1269852 
  16. Wahab, F., Tanzeela, R., Shahab, M. (2011): Study of the effect of peripheral kisspeptin administration on basal and glucose-induced insulin secretion under fed and fasting conditions in the adult male rhesus monkey (Macaca mulatta). Hormone and Metabolic Research 43(1), 37-42. http://dx.doi.org/10.1055/s-0030-1268458 
  17. Wahab, F., Bano, R., Jabeen, S., Irfan, S., Shahab, M. (2010):Effect of peripheral kisspeptin administration on adiponectin, leptin, and resistin secretion under fed and fasting condition in the adult male rhesus monkey (Macaca mulatta). Hormone and Metabolic Research 42(8), 570-74. http://dx.doi.org/10.1055/s-0030-1252016 
  18. Wahab, F., Aziz, F., Irfan, S., Zaman, U., Shahab, M. (2008): Short-term fasting attenuates the response of the HPG axis to kisspeptin challenge in the adult male rhesus monkey (Macaca mulatta). Life Sciences 83, 633-637.  http://dx.doi.org/10.1016/j.lfs.2008.09.001 
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