2024

Oneto, A; Hamwi, GA; Schäkel, L; Krüger, N; Sylvester, K; Petry, M; Shamleh, RA; Pillaiyar, T; Claff, T; Schiedel, AC; Sträter, N; Gütschow, M; Müller, CE. Nonpeptidic Irreversible Inhibitors of SARS-CoV-2 Main Protease with Potent Antiviral Activity. In: J Med Chem. 2024 Aug 15. doi: 10.1021/acs.jmedchem.4c00535.

Stahl-Hennig, C; Peter, AS; Cordsmeier, A; Stolte-Leeb, N; Vestweber, R; Socher, E; Merida, SA; Sauermann, U; Bleyer, M; Fraedrich, K; Grunwald, T; Winkler, TH; Ensser, A; Jäck, H-M; Überla, K. Genetic barrier to resistance: a critical parameter for efficacy of neutralizing monoclonal antibodies against SARS-CoV-2 in a nonhuman primate model. In: J Virol. 2024 Jul 23;98(7):e0062824. doi: 10.1128/jvi.00628-24.

Hasan, MZ; Claus, M; Krüger, N; Reusing, S; Gall, E; Bade-Döding, C; Braun, A; Watzl, C; Uhrberg, M; Walter, L. SARS-CoV-2 infection induces adaptive NK cell responses by spike protein-mediated induction of HLA-E expression. In: Emerg Microbes Infect. 2024 Dec;13(1):2361019. doi: 10.1080/22221751.2024.2361019.

Flury, P; Breidenbach, J; Krüger, N; Voget, R; Schäkel, L; Si, Y; Krasniqi, V; Calistri, S; Olfert, M; Sylvester, K; Rocha, C; Ditzinger, R; Rasch, A; Pöhlmann, S; Kronenberger, T; Poso, A; Rox, K; Laufer, SA; Müller, CE; Gütschow, M; Pillaiyar, T. Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity. In: ACS Pharmacology & Translational Science. 2024, 7, 2, 493–514. doi: 10.1021/acsptsci.3c00313.

Kaiser, FK; Hernandez, MG; Krüger, N; Englund, E; Du, W; Mykytyn, AZ; Raadsen, MP; Lamers, MM; Rodrigues Ianiski, F; Shamorkina, TM; Snijder, J; Armando, F; Beythien, G; Ciurkiewicz, M; Schreiner, T; Gruber-Dujardin, E; Bleyer, M; Batura, O; Erffmeier, L; Hinkel, R; Rocha, C; Mirolo, M; Drabek, D; Bosch, BJ; Emalfarb, M; Valbuena, N; Tchelet, R; Baumgärtner, W; Saloheimo, M; Pöhlmann, S; Grosveld, F; Haagmans, BL; Osterhaus, ADME. Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models. In: Nat Commun. 2024 Mar 14;15(1):2319. doi: 10.1038/s41467-024-46443-0.

2023

Krüger, N; Kronenberger, T; Xie, H; Rocha, C; Pöhlmann, S; Su, H; Xu, Y; Laufer, SA; Pillaiyar, T
Discovery of Polyphenolic Natural Products as SARS-CoV-2M^pro Inhibitors for COVID-19
In: Pharmaceuticals 2023,16(2), 190: doi: 10,3390/ph/16020190
Budhadev, D; Hooper, J; Rocha, C; Nehlmeier, I; Kempf, AM; Hoffmann, M; Krüger, N; Zhou, D; Pöhlmann, S; Guo, Y
Polyvalent Nano-Lectin Potently Neutralizes SARS-CoV-2 by Targeting Glycans on the Viral Spike Protein
In: JACS Au; 2023, 3(6):1755-1766, doi: 10.1021/jacsau.3c00163
Kaboudi, N; Krüger, N; Hamzeh-Mivehroud, M
Development of novel ligands against SARS-CoV-2 M pro enzyme: An in silico and in vitro study
In: Molecular Informatics, 2023 Aug 17:e2300120, doi: 10.1002/minf.202300120
Laliberté, A; Prelli Bozzo, C; Stahl-Hennig, C; Hunszinger, V; Joas, S; Sauermann, U; Roshani, B; Klippert, A; Daskalaki, M; Mätz-Rensing, K; Stolte-Leeb, N; Tharp, GK; Fuchs, D; Gupta, PM; Silvestri, G; Nelson, SA; Parodi, L; Giavedoni, L; Bosinger, SE; Sparrer, KMJ; Kirchhoff, F
Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIV_mac239 in rhesus macaques.
In: iScience. 2023 Oct 26;26(12):108351. doi: 10.1016/j.isci.2023.108351.
Stab, V; Stahl-Hennig, C; Ensser, A; Richel, E; Fraedrich, K; Sauermann, U; Tippler, B; Klein, F; Burton, DR; Tenbusch, M; Überla, K
HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells.
In: Cell Rep Med. 2023 Oct 17;4(10):101201. doi: 10.1016/j.xcrm.2023.101201.
Festag, J; Festag, MM; Asen, T; Wettengel, JM; Mück-Häusl, MA; Abdulhaqq, S; Stahl-Hennig, C; Sacha, JB; Burwitz, BJ; Protzer, U; Wisskirchen, K
Vector-Mediated Delivery of Human Major Histocompatibility Complex-I into Hepatocytes Enables Investigation of T Cell Receptor-Redirected Hepatitis B Virus-Specific T Cells in Mice, and in Macaque Cell Cultures.
In: Hum Gene Ther. 2023 Dec;34(23-24):1204-1218. doi: 10.1089/hum.2023.035.