Menü mobile menu


Frau Prof. Dr. Rabea Hinkel wechselte nach einem Veterinärmedizinischen-Studium in Gießen an die Innere Medizin der Ludwig-Maximilians-Universität München, wo sie 2009 ihre Doktorarbeit abschloss. Als PostDoc und Fachtierärztin für Versuchstierkunde arbeitete Rabea Hinkel zunächst an der LMU München, bevor sie 2015 in die Innere Medizin des Klinikums rechts der Isar der TU München und an das Institut für Prophylaxe und Epidemiologie der Herzkreislauferkrankungen der LMU wechselte. In 2017 hat sie einen der begehrten Starting Grants des Europäischen Forschungsrats (ERC) erhalten, um die Auswirkungen von Diabetes auf kleine Blutgefäße am Herzmuskel zu erforschen. Ihrem Forschungsschwerpunkt, der Herzinsuffizienz in verschiedenen Tiermodellen mit starkem Bezug zur klinischen Anwendung, wird sie auch in Göttingen treu bleiben.



Schoger, Eric; Bleckwedel, Federico; Germena, Giulia; Rocha, Cheila; Tucholla, Petra; Sobitov, Izzatullo et al. 
Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling.
In: Commun Biol 6 (1), S. 331.

Boos, Frederike; Oo, James A.; Warwick, Timothy; Günther, Stefan; Izquierdo Ponce, Judit; Lopez, Melina et al. (2023):
The endothelial-enriched lncRNA LINC00607 mediates angiogenic function.
In: Basic Res Cardiol 118 (1), S. 52.

Samak, Mostafa; Kues, Andreas; Kaltenborn, Diana; Klösener, Lina; Mietsch, Matthias; Germena, Giulia; Hinkel, Rabea
Dysregulation of Krüppel-like Factor 2 and Myocyte Enhancer Factor 2D Drive Cardiac Microvascular Inflammation and Dysfunction in Diabetes.
In: IJMS 24 (3), S. 2482.

Wang, Xiaoqing; Rosenzweig, Sebastian; Roeloffs, Volkert; Blumenthal, Moritz; Scholand, Nick; Tan, Zhengguo et al.
Free‐breathing myocardial T 1 mapping using inversion‐recovery radial FLASH and motion‐resolved model‐based reconstruction.
In: Magnetic Resonance in Med 29, S. 1956.

Klösener, Lina; Samolovac, Sabine; Barnekow, Ina; König, Jessica; Moussavi, Amir; Boretius, Susann et al. 
Functional Cardiovascular Characterization of the Common Marmoset (Callithrix jacchus).
In: ‚Biology‘ 12 (8), S. 1123.




Bozoglu, Tarik; Lee, Seungmin; Ziegler, Tilman; Jurisch, Victoria; Maas, Sanne; Baehr, Andrea et al.
Endothelial Retargeting of AAV9 In Vivo.
In: Advanced Science 118 (10), S. 2103867

Diaz-Maue, Laura; Steinebach, Janna; Richter, Claudia
Patterned Illumination Techniques in Optogenetics: An Insight Into Decelerating Murine Hearts.
In: Front. Physiol. 12, S. 3894.

Germena, Giulia; Zelarayán, Laura Cecilia; Hinkel, Rabea
Cellular Chitchatting: Exploring the Role of Exosomes as Cardiovascular Risk Factors
In: Front. Cell Dev. Biol. 10, S. 196.

Ishikawa, Kiyotake; Samolovac, Sabine; Hinkel, Rabea
Methods in Molecular Biology. Locked Nucleic Acid AntimiR Therapy for the Heart
In: Methods Mol Biol. 2573 (5), S. 159–169.

Schueler, Stephan; Bowles, Christopher T.; Hinkel, Rabea; Wohlfarth, Robert; Schmid, Michael R.; Wildhirt, Stephen et al. (2022):
A novel intrapericardial pulsatile device for individualized, biventricular circulatory support without direct blood contact.
In: The Journal of Thoracic and Cardiovascular Surgery 6 (Suppl 2), S. 606.

Haverkamp, Silke; Mietsch, Matthias; Briggman, Kevin L.
Developmental errors in the common marmoset retina
In: Front. Neuroanat. 16, S. 35.

Haverkamp, Silke; Reinhard, Katja; Peichl, Leo; Mietsch, Matthias
No evidence for age-related alterations in the marmoset retina.
In: Front. Neuroanat. 16, S. 339.

Nitsche, Steffen; Khani, Mohammad H.; Karamanlis, Dimokratis; Erol, Yunus C.; Zapp, Sören J.; Mietsch, Matthias et al.
Diversity of Ganglion Cell Responses to Saccade-like Image Shifts in the Primate Retina
In: BioRxiv 22, S. 789.

Bleckwedel, Federico; Germena, Giulia; Hinkel, Rabea; Zelarayán, Laura C.
Novel methods and insights: A profound look at the function of extracellular vesicles.
An optimized protocol for the enrichment of small vesicles from murine and non-human primate heart tissue.
In: TEV 4 (1), S. 26–33.

Drummer, Charis; Münzker, Julia; Heistermann, Michael; Becker, Tamara; Mißbach, Sophie; Behr, Rüdiger
Performance of Marmoset Monkeys as Embryo Donors Is Reflected by Different Stress-Related Parameters.
In: Animals 12 (18), S. 2414.

Wang, Xiaoqing; Rosenzweig, Sebastian; Roeloffs, Volkert; Blumenthal, Moritz; Scholand, Nick; Tan, Zhengguo et al.
Free‐breathing myocardial T 1 mapping using inversion‐recovery radial FLASH and motion‐resolved model‐based reconstruction.
In: Magnetic Resonance in Med 29, S. 1956.




Hinkel, Rabea; Batkai, Sandor; Bähr, Andrea; Bozoglu, Tarik; Straub, Sarah; Borchert, Tobias et al.
AntimiR-132 Attenuates Myocardial Hypertrophy in an Animal Model of Percutaneous Aortic Constriction.
In: Journal of the American College of Cardiology 77 (23), S. 2923–2935.

Mietsch, Matthias; Hinkel, Rabea
“Empowering” Cardiac Cells Via Stem Cell Derived Mitochondrial Transplantation- Does Age Matter?
In: IJMS 22 (4), S. 1824.

Bouteldja, Nassim; Klinkhammer, Barbara M.; Bülow, Roman D.; Droste, Patrick; Otten, Simon W.; Freifrau von Stillfried, Saskia et al.
Deep Learning–Based Segmentation and Quantification in Experimental Kidney Histopathology.
In: JASN 16, S. ASN.2020050597.

Germena, Giulia; Hinkel, Rabea
iPSCs and Exosomes: Partners in Crime Fighting Cardiovascular Diseases.
In: JPM 11 (6), S. 529.

Richter, Claudia; Hinkel, Rabea
Research('s) Sweet Hearts: Experimental Biomedical Models of Diabetic Cardiomyopathy.
In: Front. Cardiovasc. Med. 8, S. 315.

Diaz-Maue, Laura; Steinebach, Janna; Schwaerzle, Michael; Luther, Stefan; Ruther, Patrick; Richter, Claudia
Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts.
In: JoVE (174).

Müllenbroich, M. Caroline; Kelly, Allen; Acker, Corey; Bub, Gil; Bruegmann, Tobias; Di Bona, Anna et al. (2021):
Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review.
In: Front. Physiol. 12, S. 699.

Khan, Amara; Ramos-Gomes, Fernanda; Markus, Andrea; Mietsch, Matthias; Hinkel, Rabea; Alves, Frauke
Label-free imaging of age-related cardiac structural changes in non-human primates using multiphoton nonlinear microscopy.
In: Biomed. Opt. Express 12 (11), S. 7009.

Samak, Mostafa; Kaltenborn, Diana; Kues, Andreas; Le Noble, Ferdinand; Hinkel, Rabea; Germena, Giulia
Micro-RNA 92a as a Therapeutic Target for Cardiac Microvascular Dysfunction in Diabetes.
In: Biomedicines 10 (1), S. 58.



Hinkel, Rabea; Ramanujam, Deepak; Kaczmarek, Veronika; Howe, Andrea; Klett, Katharina; Beck, Christina et al.
AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury.
Journal of the American College of Cardiology 75 (15), S. 1788–1800.

Baehr, Andrea; Hinkel, Rabea; Kupatt, Christian
Statins Make a Difference in Acute Myocardial Infarction.
In: Journal of the American College of Cardiology 75 (12), S. 1403–1405.

Mietsch, Matthias; Paqué, Kristina; Drummer, Charis; Stahl-Hennig, Christiane; Roshani, Berit
The aging common marmoset's immune system: From junior to senior.
In: Am J Primatol 53 (4), S. e23128.

Moussavi, Amir; Mietsch, Matthias; Drummer, Charis; Behr, Rüdiger; Mylius, Judith; Boretius, Susann
Cardiac MRI in common marmosets revealing age-dependency of cardiac function
In: Scientific Reports 53, S. 383.

Baehr, Andrea; Umansky, Kfir Baruch; Bassat, Elad; Jurisch, Victoria; Klett, Katharina; Bozoglu, Tarik et al.
Agrin Promotes Coordinated Therapeutic Processes Leading to Improved Cardiac Repair in Pigs.
In: Circulation 133, S. 447.

Klems, Alina; van Rijssel, Jos; Ramms, Anne S.; Wild, Raphael; Hammer, Julia; Merkel, Melanie et al.
The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models.
In: Nat Commun 11 (1), S. 1712.

Bouteldja, Nassim; Klinkhammer, Barbara M.; Bülow, Roman D.; Droste, Patrick; Otten, Simon W.; Freifrau von Stillfried, Saskia et al.
Deep Learning–Based Segmentation and Quantification in Experimental Kidney Histopathology.
In: JASN 16, S. ASN.2020050597.


Ferraro B, Leoni G, Hinkel R, Ormanns S, Paulin N, Ortega-Gomez A, Viola J R, Jong R de, Bongiovanni D, Bozoglu T, Maas S L, D’Amico M, Kessler T, Zeller T, Hristov M, Reutelingsperger C, Sager H B, Döring Y, Nahrendorf M, Kupatt C, Soehnlein O
Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair.
Journal of the American College of Cardiology 73 (23 ): 2990–3002.

Scherer K, Hammel J, Sellerer T, Mechlem K, Renger B, Bähr A, Kupatt C, Hinkel R, Herzen J, Pfeiffer F, Rummeny E, Pfeiffer D
Dynamic Quantitative Iodine Myocardial Perfusion Imaging with Dual-Layer CT using a Porcine Model.
Sci Rep 9 (1 ): 29.

Samak M, Hinkel R
Stem Cells in Cardiovascular Medicine: Historical Overview and Future Prospects.
Cells 8 (12 ): 1530.


Ziegler T, Ishikawa K, Hinkel R, Kupatt C.
Translational Aspects of Adeno-Associated Virus-Mediated Cardiac Gene Therapy.
Hum Gene Ther. 2018 Jul 24. doi: 10.1089/hum.2017.229.

Ziegler T, Bähr A, Howe A, Klett K, Husada W, Weber C, Laugwitz KL, Kupatt C, Hinkel R.
Tβ4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs.
Mol Ther. 2018 Jul 5;26(7):1706-1714. doi: 10.1016/j.ymthe.2018.06.004. Epub 2018 Jun 19.

Jagschies L, Hirschvogel M, Matallo J, Maier A, Mild K, Brunner H, Hinkel R, Gee MW, Radermacher P, Wildhirt SM, Hafner S.
Individualized Biventricular Epicardial Augmentation Technology in a Drug-Induced Porcine Failing Heart Model.
ASAIO J. 2018 Jul/Aug;64(4):480-488. doi: 10.1097/MAT.0000000000000686.

Hinkel R, Klett K, Bähr A, Kupatt C.
Thymosin β4-mediated protective effects in the heart.
Expert Opin Biol Ther. 2018 Jul;18(sup1):121-129. doi: 10.1080/14712598.2018.1490409.

Ziegler T, Hinkel R, Kupatt C.
Induced pluripotent stem cell derived cardiac models: effects of Thymosin β4.
Expert Opin Biol Ther. 2018 Jul;18(sup1):111-120. doi: 10.1080/14712598.2018.1473370.

Dorn T, Kornherr J, Parrotta EI, Zawada D, Ayetey H, Santamaria G, Iop L, Mastantuono E, Sinnecker D, Goedel A, Dirschinger RJ, My I, Laue S, Bozoglu T, Baarlink C, Ziegler T, Graf E, Hinkel R, Cuda G, Kääb S, Grace AA, Grosse R, Kupatt C, Meitinger T, Smith AG, Laugwitz KL, Moretti A.
Interplay of cell-cell contacts and RhoA/MRTF-A signaling regulates cardiomyocyte identity.
EMBO J. 2018 Jun 15;37(12). pii: e98133. doi: 10.15252/embj.201798133. Epub 2018 May 15.

Längin M, Mayr T, Reichart B, Michel S, Buchholz S, Guethoff S, Dashkevich A, Baehr A, Egerer S, Bauer A, Mihalj M, Panelli A, Issl L, Ying J, Fresch A K, Buttgereit I, Mokelke M, Radan J, Werner F, Lutzmann I, Steen S, Sjöberg T, Paskevicius A, Qiuming L, Sfriso R, Rieben R, Dahlhoff M, Kessler B, Kemter E, Klett K, Hinkel R, Kupatt C, Falkenau A, Reu S, Ellgass R, Herzog R, Binder U, Wich G, Skerra A, Ayares D, Kind A, Schönmann U, Kaup F-J, Hagl C, Wolf E, Klymiuk N, Brenner P, Abicht J-M
Consistent success in life-supporting porcine cardiac xenotransplantation.
In: Nature 36 : 1037.


Ziegler T, Kraus M, Husada W, Gesenhues F, Jiang Q, Pinkenburg O, Trenkwalder T, Laugwitz KL, le Noble F, Weber C, Kupatt C, Hinkel R.

Steerable Induction of the Thymosin β4/MRTF-A Pathway via AAV-Based Overexpression Induces Therapeutic Neovascularization.
Hum Gene Ther. 2017 Oct 3. doi: 10.1089/hum.2017.013. [Epub ahead of print]

Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, Krishnasamy K, Limbourg A, Häger C, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP.
Corrigendum: Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.
Nat Commun. 2017 May 3;8:15486. doi: 10.1038/ncomms15486. No abstract available.

Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A, Laugwitz KL, Sinnecker D.
Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes.
Eur Heart J. 2017 Jan 21;38(4):292-301. doi: 10.1093/eurheartj/ehw189. No abstract available.

Hinkel R, Howe A, Renner S, Ng J, Lee S, Klett K, Kaczmarek V, Moretti A, Laugwitz KL, Skroblin P, Mayr M, Milting H, Dendorfer A, Reichart B, Wolf E, Kupatt C.
Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium.
J Am Coll Cardiol. 2017 Jan 17;69(2):131-143. doi: 10.1016/j.jacc.2016.10.058.

Hinkel R, Kupatt C.
Selective Pressure-Regulated Retroinfusion for Gene Therapy Application in Ischemic Heart Disease.
Methods Mol Biol. 2017;1521:249-260.

Ziegler T, Hinkel R, Stöhr A, Eschenhagen T, Laugwitz KL, le Noble F, David R, Hansen A, Kupatt C.
Thymosin β4 Improves Differentiation and Vascularization of EHTs.
Stem Cells Int. 2017;2017:6848271. doi: 10.1155/2017/6848271. Epub 2017 Jan 16.