After studying veterinary medicine in Gießen, Mrs. Prof. Dr. Rabea Hinkel moved to internal medicine at the Ludwig-Maximilians-Universität München, where she completed her PhD in 2009. Rabea Hinkel initially worked at the LMU Munich as a postdoc and veterinary specialist for experimental animal science. In the year 2015 she moved to internal medicine at the Klinikum rechts der Isar of the TU Munich and to the Institute for Prophylaxis and Epidemiology of Cardiovascular Diseases at the LMU. In 2017, she received one of the coveted Starting Grants from the European Research Council (ERC) to explore the effects of diabetes on small blood vessels on the heart muscle. Her research focus, heart failure in different animal models with a strong relation to clinical application, will remain true to her in Göttingen.
2023
Schoger, Eric; Bleckwedel, Federico; Germena, Giulia; Rocha, Cheila; Tucholla, Petra; Sobitov, Izzatullo et al.
Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling.
In: Commun Biol 6 (1), S. 331.
Boos, Frederike; Oo, James A.; Warwick, Timothy; Günther, Stefan; Izquierdo Ponce, Judit; Lopez, Melina et al. (2023):
The endothelial-enriched lncRNA LINC00607 mediates angiogenic function.
In: Basic Res Cardiol 118 (1), S. 52.
Samak, Mostafa; Kues, Andreas; Kaltenborn, Diana; Klösener, Lina; Mietsch, Matthias; Germena, Giulia; Hinkel, Rabea
Dysregulation of Krüppel-like Factor 2 and Myocyte Enhancer Factor 2D Drive Cardiac Microvascular Inflammation and Dysfunction in Diabetes.
In: IJMS 24 (3), S. 2482.
Wang, Xiaoqing; Rosenzweig, Sebastian; Roeloffs, Volkert; Blumenthal, Moritz; Scholand, Nick; Tan, Zhengguo et al.
Free‐breathing myocardial T 1 mapping using inversion‐recovery radial FLASH and motion‐resolved model‐based reconstruction.
In: Magnetic Resonance in Med 29, S. 1956.
Klösener, Lina; Samolovac, Sabine; Barnekow, Ina; König, Jessica; Moussavi, Amir; Boretius, Susann et al.
Functional Cardiovascular Characterization of the Common Marmoset (Callithrix jacchus).
In: ‚Biology‘ 12 (8), S. 1123.
Eiringhaus, Jörg; Vries, Anna-Lena de; Hohmann, Stephan; Böthig, Dietmar; Müller-Leisse, Johanna; Hillmann, Henrike A.K et al.
Performance and feasibility of three different approaches for computer based semi-automated analysis of ventricular arrhythmias in telemetric long-term ECG in cynomolgus monkeys.
In: Journal of Pharmacological and Toxicological Methods 124 (5), S. 107471.
Krüppel, Steffen; Khani, Mohammad H.; Karamanlis, Dimokratis; Erol, Yunus C.; Zapp, Sören J.; Mietsch, Matthias et al.
Diversity of Ganglion Cell Responses to Saccade-Like Image Shifts in the Primate Retina.
In: J. Neurosci. 43 (29), S. 5319–5339.
Schueler, Stephan; Bowles, Christopher T.; Hinkel, Rabea; Wohlfarth, Robert; Schmid, Michael R.; Wildhirt, Stephen et al.
A novel intrapericardial pulsatile device for individualized, biventricular circulatory support without direct blood contact.
In: The Journal of Thoracic and Cardiovascular Surgery 6 (Suppl 2), S. 606.
Svetlove, Angelika; Ritter, Christian O.; Dullin, Christian; Schmid, Michael; Schauer, Senta; Uihlein, Johannes et al.
Evaluation of MR-safe bioptomes for MR-guided endomyocardial biopsy in minipigs: a potential radiation-free clinical approach.
In: Eur Radiol Exp 7 (1), S. 854.
Hussaini, Sayedeh; Lädke, Sarah L.; Schröder-Schetelig, Johannes; Venkatesan, Vishalini; Quiñonez Uribe, Raúl A.; Richter, Claudia et al.
Dissolution of spiral wave’s core using cardiac optogenetics.
In: PLoS Comput Biol 19 (12), S. e1011660.
2021
Hinkel, Rabea; Batkai, Sandor; Bähr, Andrea; Bozoglu, Tarik; Straub, Sarah; Borchert, Tobias et al.
AntimiR-132 Attenuates Myocardial Hypertrophy in an Animal Model of Percutaneous Aortic Constriction.
In: Journal of the American College of Cardiology 77 (23), S. 2923–2935.
Mietsch, Matthias; Hinkel, Rabea
“Empowering” Cardiac Cells Via Stem Cell Derived Mitochondrial Transplantation- Does Age Matter?
In: IJMS 22 (4), S. 1824.
Bouteldja, Nassim; Klinkhammer, Barbara M.; Bülow, Roman D.; Droste, Patrick; Otten, Simon W.; Freifrau von Stillfried, Saskia et al.
Deep Learning–Based Segmentation and Quantification in Experimental Kidney Histopathology.
In: JASN 16, S. ASN.2020050597.
Germena, Giulia; Hinkel, Rabea
iPSCs and Exosomes: Partners in Crime Fighting Cardiovascular Diseases.
In: JPM 11 (6), S. 529.
Richter, Claudia; Hinkel, Rabea
Research('s) Sweet Hearts: Experimental Biomedical Models of Diabetic Cardiomyopathy.
In: Front. Cardiovasc. Med. 8, S. 315.
Diaz-Maue, Laura; Steinebach, Janna; Schwaerzle, Michael; Luther, Stefan; Ruther, Patrick; Richter, Claudia
Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts.
In: JoVE (174).
Müllenbroich, M. Caroline; Kelly, Allen; Acker, Corey; Bub, Gil; Bruegmann, Tobias; Di Bona, Anna et al. (2021):
Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review.
In: Front. Physiol. 12, S. 699.
Khan, Amara; Ramos-Gomes, Fernanda; Markus, Andrea; Mietsch, Matthias; Hinkel, Rabea; Alves, Frauke
Label-free imaging of age-related cardiac structural changes in non-human primates using multiphoton nonlinear microscopy.
In: Biomed. Opt. Express 12 (11), S. 7009.
Samak, Mostafa; Kaltenborn, Diana; Kues, Andreas; Le Noble, Ferdinand; Hinkel, Rabea; Germena, Giulia
Micro-RNA 92a as a Therapeutic Target for Cardiac Microvascular Dysfunction in Diabetes.
In: Biomedicines 10 (1), S. 58.
2020
Hinkel, Rabea; Ramanujam, Deepak; Kaczmarek, Veronika; Howe, Andrea; Klett, Katharina; Beck, Christina et al.
AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury.
Journal of the American College of Cardiology 75 (15), S. 1788–1800.
Baehr, Andrea; Hinkel, Rabea; Kupatt, Christian
Statins Make a Difference in Acute Myocardial Infarction.
In: Journal of the American College of Cardiology 75 (12), S. 1403–1405.
Mietsch, Matthias; Paqué, Kristina; Drummer, Charis; Stahl-Hennig, Christiane; Roshani, Berit
The aging common marmoset's immune system: From junior to senior.
In: Am J Primatol 53 (4), S. e23128.
Moussavi, Amir; Mietsch, Matthias; Drummer, Charis; Behr, Rüdiger; Mylius, Judith; Boretius, Susann
Cardiac MRI in common marmosets revealing age-dependency of cardiac function
In: Scientific Reports 53, S. 383.
Baehr, Andrea; Umansky, Kfir Baruch; Bassat, Elad; Jurisch, Victoria; Klett, Katharina; Bozoglu, Tarik et al.
Agrin Promotes Coordinated Therapeutic Processes Leading to Improved Cardiac Repair in Pigs.
In: Circulation 133, S. 447.
Klems, Alina; van Rijssel, Jos; Ramms, Anne S.; Wild, Raphael; Hammer, Julia; Merkel, Melanie et al.
The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models.
In: Nat Commun 11 (1), S. 1712.
Bouteldja, Nassim; Klinkhammer, Barbara M.; Bülow, Roman D.; Droste, Patrick; Otten, Simon W.; Freifrau von Stillfried, Saskia et al.
Deep Learning–Based Segmentation and Quantification in Experimental Kidney Histopathology.
In: JASN 16, S. ASN.2020050597.
2019
Ferraro B, Leoni G, Hinkel R, Ormanns S, Paulin N, Ortega-Gomez A, Viola J R, Jong R de, Bongiovanni D, Bozoglu T, Maas S L, D’Amico M, Kessler T, Zeller T, Hristov M, Reutelingsperger C, Sager H B, Döring Y, Nahrendorf M, Kupatt C, Soehnlein O
Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair.
Journal of the American College of Cardiology 73 (23 ): 2990–3002.
Scherer K, Hammel J, Sellerer T, Mechlem K, Renger B, Bähr A, Kupatt C, Hinkel R, Herzen J, Pfeiffer F, Rummeny E, Pfeiffer D
Dynamic Quantitative Iodine Myocardial Perfusion Imaging with Dual-Layer CT using a Porcine Model.
Sci Rep 9 (1 ): 29.
Samak M, Hinkel R
Stem Cells in Cardiovascular Medicine: Historical Overview and Future Prospects.
Cells 8 (12 ): 1530.
2018
Ziegler T, Ishikawa K, Hinkel R, Kupatt C.
Translational Aspects of Adeno-Associated Virus-Mediated Cardiac Gene Therapy.
Hum Gene Ther. 2018 Jul 24. doi: 10.1089/hum.2017.229.
Ziegler T, Bähr A, Howe A, Klett K, Husada W, Weber C, Laugwitz KL, Kupatt C, Hinkel R.
Tβ4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs.
Mol Ther. 2018 Jul 5;26(7):1706-1714. doi: 10.1016/j.ymthe.2018.06.004. Epub 2018 Jun 19.
Jagschies L, Hirschvogel M, Matallo J, Maier A, Mild K, Brunner H, Hinkel R, Gee MW, Radermacher P, Wildhirt SM, Hafner S.
Individualized Biventricular Epicardial Augmentation Technology in a Drug-Induced Porcine Failing Heart Model.
ASAIO J. 2018 Jul/Aug;64(4):480-488. doi: 10.1097/MAT.0000000000000686.
Hinkel R, Klett K, Bähr A, Kupatt C.
Thymosin β4-mediated protective effects in the heart.
Expert Opin Biol Ther. 2018 Jul;18(sup1):121-129. doi: 10.1080/14712598.2018.1490409.
Ziegler T, Hinkel R, Kupatt C.
Induced pluripotent stem cell derived cardiac models: effects of Thymosin β4.
Expert Opin Biol Ther. 2018 Jul;18(sup1):111-120. doi: 10.1080/14712598.2018.1473370.
Dorn T, Kornherr J, Parrotta EI, Zawada D, Ayetey H, Santamaria G, Iop L, Mastantuono E, Sinnecker D, Goedel A, Dirschinger RJ, My I, Laue S, Bozoglu T, Baarlink C, Ziegler T, Graf E, Hinkel R, Cuda G, Kääb S, Grace AA, Grosse R, Kupatt C, Meitinger T, Smith AG, Laugwitz KL, Moretti A.
Interplay of cell-cell contacts and RhoA/MRTF-A signaling regulates cardiomyocyte identity.
EMBO J. 2018 Jun 15;37(12). pii: e98133. doi: 10.15252/embj.201798133. Epub 2018 May 15.
Längin M, Mayr T, Reichart B, Michel S, Buchholz S, Guethoff S, Dashkevich A, Baehr A, Egerer S, Bauer A, Mihalj M, Panelli A, Issl L, Ying J, Fresch A K, Buttgereit I, Mokelke M, Radan J, Werner F, Lutzmann I, Steen S, Sjöberg T, Paskevicius A, Qiuming L, Sfriso R, Rieben R, Dahlhoff M, Kessler B, Kemter E, Klett K, Hinkel R, Kupatt C, Falkenau A, Reu S, Ellgass R, Herzog R, Binder U, Wich G, Skerra A, Ayares D, Kind A, Schönmann U, Kaup F-J, Hagl C, Wolf E, Klymiuk N, Brenner P, Abicht J-M
Consistent success in life-supporting porcine cardiac xenotransplantation.
In: Nature 36 : 1037.
2017
Ziegler T, Kraus M, Husada W, Gesenhues F, Jiang Q, Pinkenburg O, Trenkwalder T, Laugwitz KL, le Noble F, Weber C, Kupatt C, Hinkel R.
Steerable Induction of the Thymosin β4/MRTF-A Pathway via AAV-Based Overexpression Induces Therapeutic Neovascularization.
Hum Gene Ther. 2017 Oct 3. doi: 10.1089/hum.2017.013. [Epub ahead of print]
Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, Krishnasamy K, Limbourg A, Häger C, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP.
Corrigendum: Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.
Nat Commun. 2017 May 3;8:15486. doi: 10.1038/ncomms15486. No abstract available.
Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A, Laugwitz KL, Sinnecker D.
Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes.
Eur Heart J. 2017 Jan 21;38(4):292-301. doi: 10.1093/eurheartj/ehw189. No abstract available.
Hinkel R, Howe A, Renner S, Ng J, Lee S, Klett K, Kaczmarek V, Moretti A, Laugwitz KL, Skroblin P, Mayr M, Milting H, Dendorfer A, Reichart B, Wolf E, Kupatt C.
Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium.
J Am Coll Cardiol. 2017 Jan 17;69(2):131-143. doi: 10.1016/j.jacc.2016.10.058.
Hinkel R, Kupatt C.
Selective Pressure-Regulated Retroinfusion for Gene Therapy Application in Ischemic Heart Disease.
Methods Mol Biol. 2017;1521:249-260.
Ziegler T, Hinkel R, Stöhr A, Eschenhagen T, Laugwitz KL, le Noble F, David R, Hansen A, Kupatt C.
Thymosin β4 Improves Differentiation and Vascularization of EHTs.
Stem Cells Int. 2017;2017:6848271. doi: 10.1155/2017/6848271. Epub 2017 Jan 16.