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After studying veterinary medicine in Gießen, Mrs. Prof. Dr. Rabea Hinkel moved to internal medicine at the Ludwig-Maximilians-Universität München, where she completed her PhD in 2009. Rabea Hinkel initially worked at the LMU Munich as a postdoc and veterinary specialist for experimental animal science. In the year 2015 she moved to internal medicine at the Klinikum rechts der Isar of the TU Munich and to the Institute for Prophylaxis and Epidemiology of Cardiovascular Diseases at the LMU. In 2017, she received one of the coveted Starting Grants from the European Research Council (ERC) to explore the effects of diabetes on small blood vessels on the heart muscle. Her research focus, heart failure in different animal models with a strong relation to clinical application, will remain true to her in Göttingen.


2018

Ziegler T, Ishikawa K, Hinkel R, Kupatt C.
Translational Aspects of Adeno-Associated Virus-Mediated Cardiac Gene Therapy.
Hum Gene Ther. 2018 Jul 24. doi: 10.1089/hum.2017.229.

Ziegler T, Bähr A, Howe A, Klett K, Husada W, Weber C, Laugwitz KL, Kupatt C, Hinkel R.
Tβ4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs.
Mol Ther. 2018 Jul 5;26(7):1706-1714. doi: 10.1016/j.ymthe.2018.06.004. Epub 2018 Jun 19.

Jagschies L, Hirschvogel M, Matallo J, Maier A, Mild K, Brunner H, Hinkel R, Gee MW, Radermacher P, Wildhirt SM, Hafner S.
Individualized Biventricular Epicardial Augmentation Technology in a Drug-Induced Porcine Failing Heart Model.
ASAIO J. 2018 Jul/Aug;64(4):480-488. doi: 10.1097/MAT.0000000000000686.

Hinkel R, Klett K, Bähr A, Kupatt C.
Thymosin β4-mediated protective effects in the heart.
Expert Opin Biol Ther. 2018 Jul;18(sup1):121-129. doi: 10.1080/14712598.2018.1490409.

Ziegler T, Hinkel R, Kupatt C.
Induced pluripotent stem cell derived cardiac models: effects of Thymosin β4.
Expert Opin Biol Ther. 2018 Jul;18(sup1):111-120. doi: 10.1080/14712598.2018.1473370.

Dorn T, Kornherr J, Parrotta EI, Zawada D, Ayetey H, Santamaria G, Iop L, Mastantuono E, Sinnecker D, Goedel A, Dirschinger RJ, My I, Laue S, Bozoglu T, Baarlink C, Ziegler T, Graf E, Hinkel R, Cuda G, Kääb S, Grace AA, Grosse R, Kupatt C, Meitinger T, Smith AG, Laugwitz KL, Moretti A.
Interplay of cell-cell contacts and RhoA/MRTF-A signaling regulates cardiomyocyte identity.
EMBO J. 2018 Jun 15;37(12). pii: e98133. doi: 10.15252/embj.201798133. Epub 2018 May 15.

Längin M, Mayr T, Reichart B, Michel S, Buchholz S, Guethoff S, Dashkevich A, Baehr A, Egerer S, Bauer A, Mihalj M, Panelli A, Issl L, Ying J, Fresch A K, Buttgereit I, Mokelke M, Radan J, Werner F, Lutzmann I, Steen S, Sjöberg T, Paskevicius A, Qiuming L, Sfriso R, Rieben R, Dahlhoff M, Kessler B, Kemter E, Klett K, Hinkel R, Kupatt C, Falkenau A, Reu S, Ellgass R, Herzog R, Binder U, Wich G, Skerra A, Ayares D, Kind A, Schönmann U, Kaup F-J, Hagl C, Wolf E, Klymiuk N, Brenner P, Abicht J-M
Consistent success in life-supporting porcine cardiac xenotransplantation.
In: Nature 36 : 1037.



2017

Ziegler T, Kraus M, Husada W, Gesenhues F, Jiang Q, Pinkenburg O, Trenkwalder T, Laugwitz KL, le Noble F, Weber C, Kupatt C, Hinkel R.

Steerable Induction of the Thymosin β4/MRTF-A Pathway via AAV-Based Overexpression Induces Therapeutic Neovascularization.
Hum Gene Ther. 2017 Oct 3. doi: 10.1089/hum.2017.013. [Epub ahead of print]

Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, Krishnasamy K, Limbourg A, Häger C, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP.
Corrigendum: Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.
Nat Commun. 2017 May 3;8:15486. doi: 10.1038/ncomms15486. No abstract available.

Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A, Laugwitz KL, Sinnecker D.
Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes.
Eur Heart J. 2017 Jan 21;38(4):292-301. doi: 10.1093/eurheartj/ehw189. No abstract available.

Hinkel R, Howe A, Renner S, Ng J, Lee S, Klett K, Kaczmarek V, Moretti A, Laugwitz KL, Skroblin P, Mayr M, Milting H, Dendorfer A, Reichart B, Wolf E, Kupatt C.
Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium.
J Am Coll Cardiol. 2017 Jan 17;69(2):131-143. doi: 10.1016/j.jacc.2016.10.058.

Hinkel R, Kupatt C.
Selective Pressure-Regulated Retroinfusion for Gene Therapy Application in Ischemic Heart Disease.
Methods Mol Biol. 2017;1521:249-260.

Ziegler T, Hinkel R, Stöhr A, Eschenhagen T, Laugwitz KL, le Noble F, David R, Hansen A, Kupatt C.
Thymosin β4 Improves Differentiation and Vascularization of EHTs.
Stem Cells Int. 2017;2017:6848271. doi: 10.1155/2017/6848271. Epub 2017 Jan 16.