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SFB 127

The Transregional Collaborative Research Centre (TRR) 127 aims to dissect the biology of xenogeneic cell, tissue and organ transplantation and develop evidence-based concepts that bring xenotransplantation of porcine pancreatic islets, heart valves, and hearts from bench to bedside. Breakthroughs in macroencapsulated porcine islet transplantation into diabetic macaques and life-supporting orthotopic porcine heart transplantation into baboons have been published in leading journals, demonstrating consistent positive results in the most stringent pre-clinical models. The overarching goals of the TRR 127 are to overcome the remaining obstacles and to generate the safety and efficacy data required for submission of clinical study protocols in Europe and elsewhere.