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Prof. Dr. Melanie Wilke

Senior Scientist

Cognitive Neurosciences Laboratory, DAG

+49 551 3851-332

MWilke(at)dpz.eu

Robert-Koch-Str. 40

Kellnerweg 4
37077 Göttingen

Guest scientist/Co-Supervisor of students in the DAG group
Neurology Module 5
Mo-Fri 9-18

The long-term goal of our research is to understand how neural activity gives rise to spatial awareness and how distributed information is integrated to guide the selection of movement goals. Furthermore we are dedicated to perform translational research from monkey models of cognitive disorders to human patients. Current research focuses on the question how thalamic nuclei and cortical areas interact during visual perception and decision making. Another line of research is concerned with the neural mechanisms underlying spatial neglect, which is a frequent and severe consequence of brain damage in humans. Specifically we are investigating pathological and compensatory changes in large-scale brain networks in human stroke patients by means of imaging (DTI, fMRI) and stimulation (tACS, tDCS, TMS) methods.  We develop and employ monkey models of spatial neglect to study the underlying neural mechanisms by means of fMRI, electrophysiological recordings, inactivation and stimulation techniques with the goal to develop new therapeutic interventions.

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Publications:

 Journal Articles:

  • Cabral-Calderin, Y*., Weinrich, C.*, Schmidt-Samoa, C., Poland, E., Dechent, P., Bähr, M., Wilke, M. Transcranial alternating current stimulation affects the BOLD signal in a frequency and task-dependent manner. Human Brain Mapping. 2016 Jan;37(1):94-121.
  • Tsuchiya, N., Wilke, M., Frässle, S., Lamme, V.No-report paradigms:  Extracting the true neural correlates of consciousness. Trends in Cognitive Sciences. 2015. Nov 13. S1364-6613(15)00252-1.   
  • Paschke, K., Kagan, I., Wüstenberg, T., Bähr, M., Wilke, M. Trunk rotation affects temporal order judgments with direct saccades: influence of handedness. 2015. Neuropsychologia. 2015 Oct 27. pii: S0028-3932(15)30207-4.
  • Cabral-Calderin, Y., Schmidt-Samoa, C., Wilke, M.Rhythmic gamma stimulation affects bistable perception. Journal of Cognitive Neuroscience. 2015. 20:1-10.
  • Hwang, E., Hauschild, M., Wilke, M., Andersen, R.A. Spatial and Temporal Eye-Hand Coordination Relies on the Parietal Reach Region. Journal of Neuroscience. 2014. 34:12884-92.
  •  Wilke, M.*, Kagan, I.*, Andersen, R.A. Context-specific effects of pulvinar inactivation on fMRI signals during spatial decision making. 2014 (submitted).
  • Cabral-Calderin, Y., Schmidt-Samoa, C., Wilke, M. Rhythmic gamma stimulation affects bistable perception. Journal of Cognitive Neuroscience. 2014 (in revision).
  • Hwang, E., Hauschild, M., Wilke, M., Andersen, R.A. Spatial and Temporal Eye-Hand Coordination Relies on the Parietal Reach Region. Journal of Neuroscience. 2014. 34:12884-92.
  • Wilke, M., Kagan, I., Andersen, R.A. Effects of pulvinar inactivation on spatial decision making between equal and asymmetric reward options. Journal of Cognitive Neuroscience. 2013. 25(8), 1270-83.
  • Helms, G., Garea-Rodriguez, E., Schlumbohm, C., König, J., Dechent, P., Fuchs, E., Wilke, M. Structural and quantitative neuroimaging of the common marmoset monkey using a clinical MRI system. Journal of Neuroscience Methods. 2013. 215(1):121-31.
  • Hwang, E.J., Hauschild, M., Wilke, M., Andersen, R.A. Inactivation of the parietal reach region causes optic ataxia, impairing reaches but not saccades. Neuron. 2012. 76(5):1021-9.
  • Wilke, M.*, Kagan, I.*, Andersen R.A. Functional Imaging Reveals Rapid Reorganization of Cortical Activity after Parietal Inactivation in Monkeys. PNAS. 2012.109:8274-9.

  • Schmid, M.C., Mrowka, S., Turchi, J., Saunders, R., Wilke, M., Ye, F., Leopold, D.A. Blindsight functions depend on the lateral geniculate nucleus. Nature. 2010. 466(7304):373-7.
  • Wilke, M., Turchi, J., Smith, K., Mishkin, M., Leopold, D.A. Pulvinar inactivation disrupts selection of movement plans. Journal of Neuroscience. 2010. 30:8650-9.
  • Wilke, M, Mueller, K.M., Leopold, D.A. Visibility related modulation of neural responses invisual thalamic nuclei. PNAS. 2009. 106(23):9465-70.
  • Mueller, K.M., Wilke, M., Leopold, D.A. Neural responses in monkey area V4 following visual shape adaptation. Neuroscience. 2009. 161(2):655-62.
  • Cui, J., Wilke, M., Logothetis, N.K., Leopold, D.A, Liang, H. Visibility states modulate microsaccade rate and direction. Vision Research. 2009. 49(2):228-36.
  • Maier, A., Wilke, M., Aura, C., Zhu, C., Ye, F.Q., Leopold, D.A. Divergence of electrical and fMRI signals in primary visual cortex during perceptual suppression. Nature Neuroscience. 2008. 11(10):1193-200.
  • Wilke, M.,Logothetis, N.K., Leopold, D.A. Local field potentials reflect perceptual suppression in monkey visual cortex. PNAS. 2006. 103(46):17507-12.
  • Wilke, M., Logothetis, N.K., Leopold, D.A. Generalized flash suppression of salient visual targets. Neuron. 2003. 39(6):1043-52.
  • Maier, A., Wilke, M., Logothetis, N.K., Leopold, D.A. Perception of temporally interleaved ambiguous patterns. Current Biology. 2003. 13(13):1076-85.
  • Leopold, D.A., Wilke, M., Maier, A., Logothetis, N.K. Stable perception of visually ambiguous patterns. Nature Neuroscience. 2002. 5(6):605-9.

Reviews/Book chapter:

  • Boly, M., Seth, A., Wilke, M., Igmundson, P., Baars, D., Laureys, S., Edelman, D., Tsuchiya, N. Consciousness in humans and non-human animals: recent outstanding advances, and possible future directions. Frontiers in Consciousness Research. 2013.
  • Wilke, M., Dechent, P., Schmidt-Samoa, C. Experimentelle Modelle für räumlichen Neglect (Studien in humanen und nicht-humanen Primaten). Neuroforum. 2012. 1:178-89.
  • Leopold, D.A., Wilke, M., Neuroimaging: seeing the trees for the forest. Current Biology 2005. 15(18):766-8
  • Leopold, D.A., Maier, A., Wilke, M., Logothetis, N.K. Binocular rivalry and the illusion of monocular vision. Binocular rivalry and perceptual ambiguity. 2005. (Eds.) David Alais and Randoph Blake, MIT Press, Cambridge, MA.

Flute, Guitar, Painting

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