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Die ehemalige Abteilung Infektionsforschung (bis Dezember 2017)

Die Abteilung Infektionspathologie (Leiter: Prof. Dr. Franz-Josef Kaup) gehörte zur Sektion Infektionsforschung des Deutschen Primatenzentrums (DPZ). Der Forschungsschwerpunkt lag auf pathogenetischen Untersuchungen zu spontanen oder experimentell induzierten Infektionskrankheiten bei nicht-menschlichen Primaten unter Anwendung morphologischer Methoden.


Becker, Tamara; Pieper, Florian; Liebetanz, David; Bleyer, Martina; Schrod, Annette; Maetz-Rensing, Kerstin; Treue, Stefan
Suspect Guillain-Barré syndrome in a male rhesus macaque (Macaca mulatta).
In: Primate Biol. 4 (1), S. 27-32.

Bleyer, Martina; Kunze, Marius; Gruber-Dujardin, Eva; Mätz-Rensing, Kerstin
Spontaneous lung pathology in a captive common marmoset colony (Callithrix jacchus).
In: Primate Biol. 4 (1), S. 17-25.   

Cichon, Nicole; Lampe, Karen; Bremmer, Felix; Becker, Tamara; Mätz-Rensing, Kerstin (2017):
Unique case of granulomatous arteritis in a grey mouse lemur (Microcebus murinus) - first case description.
In: Primate Biol. 4 (1), S. 71-75.                              

Fechner, Kim; Mätz-Rensing, Kerstin; Lampe, Karen; Kaup, Franz-Josef; Czerny, Claus-Peter; Schäfer, Jenny
Detection of Mycobacterium avium subsp. paratuberculosis in non-human primates.
In: J Med Primatol 124, S. 290.    

Ferkau A; Raue K; Gruber-Dujardin E; Barkhoff M
Okuläre Onchozerkose bei einer Englischen Bulldogge mit positivem Leishmaniose-Antikörper-Titer.
In: Kleintierpraxis.              

Gruber-Dujardin, Eva; Bleyer, Martina; Mätz-Rensing, Kerstin
Morphological and immunohistochemical characterization of spontaneous endometriosis in rhesus macaques (Macaca mulatta).
In: Primate Biol. 4 (1), S. 77-91.

Hollmann, Anne K.; Bleyer, Martina; Tipold, Andrea; Neßler, Jasmin N.; Wemheuer, Wilhelm E.; Schütz, Ekkehard; Brenig, Bertram
A genome-wide association study reveals a locus for bilateral iridal hypopigmentation in Holstein Friesian cattle.
In: BMC Genet 18 (1), S. 589.

Lampe, Karen; Gottstein, B.; Becker, T.; Stahl-Hennig, C.; Kaup, F.-J; Mätz-Rensing, K.
Immunization of rhesus macaques with Echinococcus multilocularis recombinant 14-3-3 antigen leads to specific antibody response.
In: Parasitol Res.

Lampe, Karen; Rudnick, Jens-Christian; Leendertz, Fabian; Bleyer, Martina; Mätz-Rensing, Kerstin
Intravascular T-cell lymphoma in a patas monkey (Erythrocebus patas).
In: Primate Biol. 4 (1), S. 39-46.

Niehof, Monika; Hildebrandt, Tobias; Danov, Olga; Arndt, Kirsten; Koschmann, Jeannette; Dahlmann, Franziska et al.
RNA isolation from precision-cut lung slices (PCLS) from different species.
In: BMC Res Notes 10 (1), S. 118.

Pöhlmann, Stefan; Suntz, Michael; Akimkin, Valerij; Bleyer, Martina; Kaul, Artur
Herpes B virus replication and viral lesions in the liver of a cynomolgus macaque which died from severe disease with rapid onset.
In: J Med Primatol 13 (Suppl 1), S. 379.

Richard, Mathilde; Knauf, Sascha; Lawrence, Philip; Mather, Alison E.; Munster, Vincent J.; Müller, Marcel A. et al.
Factors determining human-to-human transmissibility of zoonotic pathogens via contact.
In: Current Opinion in Virology 22, S. 7-12.

Zinner, D.; Keller, C.; Butynski, T.M; Jong, Y.A de; Pozzi, L.; Knauf, S. et al.
Distribution of mitochondrial clades and morphotypes of baboons Papio spp. (Primates: Cercopithecidae) in eastern Africa.
In: Journal of East African Natural History.

Zmora, Pawel; Molau-Blazejewska, Paulina; Bertram, Stephanie; Walendy-Gnirß, Kerstin; Nehlmeier, Inga; Hartleib, Anika et al.
Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin.

Neumann, Stephan; Schuettler, Julia; Frenz, Meike; Kaup, Franz-Josef; Gessler, Frank (2017, Epub 10/16):
Investigation of serum Ki-67 as a biomarker in tumor-bearing dogs.
In: Research in Veterinary Science 110, S. 16–21.

Mietsch, Matthias; Sauermann, Ulrike; Mätz-Rensing, Kerstin; Klippert, Antonina; Daskalaki, Maria; Stolte-Leeb, Nicole; Stahl-Hennig, Christiane
Revisiting a quarter of a century of simian immunodeficiency virus (SIV)-associated cardiovascular diseases at the German Primate Center.
In: Primate Biol. 4 (1), S. 107–115.

Klegarth, Amy R.; Ezeonwu, Chigozie A.; Rompis, Aida; Lee, Benjamin P.Y.-H; Aggimarangsee, Nantiya; Chalise, Mukesh et al. 
Survey of Treponemal Infections in Free-Ranging and Captive Macaques, 1999–2012.
In: Emerg. Infect. Dis. 23 (5), S. 816–819.

Houinei, Wendy; Godornes, Charmie; Kapa, August; Knauf, Sascha; Mooring, Eric Q.; González-Beiras, Camila et al. 
Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea.
In: PLoS Negl Trop Dis 11 (5), S. e0004958.

Hoffmann, Constanze; Zimmermann, Fee; Biek, Roman; Kuehl, Hjalmar; Nowak, Kathrin; Mundry, Roger et al. 
Persistent anthrax as a major driver of wildlife mortality in a tropical rainforest.
In: Nature 548 (7665), S. 82–86.

Daskalaki, Maria; Neumann, Berit; Klippert, Antonina; Mätz-Rensing, Kerstin; Kaup, Franz-Josef; Stahl-Hennig, Christiane
Long-term efficient control of SIV infection in macaques is associated with an intact intestinal barrier.
In: J Med Primatol 46 (4), S. 144–148.

Kaup, Franz-Josef
Gorilla Pathology and Health Gorilla Pathology and Health. By John Cooper and Gordon Hull. Academic Press, London, UK. 2017. 666 pp. USA $140 (hardback); $125 (eBook).
In: Journal of Wildlife Diseases.

Mätz-Rensing, Kerstin; Yue, Constanze; Klenner, Jeanette; Ellerbrok, Heinz; Stahl-Hennig, Christiane:
Limited susceptibility of rhesus macaques to a cowpox virus isolated from a lethal outbreak among New World monkeys.
In: Primate Biol. 4 (2), S. 163–171.

Ludwig, Barbara; Ludwig, Stefan; Steffen, Anja; Knauf, Yvonne; Zimerman, Baruch; Heinke, Sophie; Lehmann, Susann; Schubert, Undine; Schmid, Janine; Bleyer, Martina; Schönmann, Uwe; Colton, Clark K.; Bonifacio, Ezio; Solimena, Michele; Reichel, Andreas; Schally, Andrew V.; Rotem, Avi; Barkai, Uriel; Grinberg-Rashi, Helena; Kaup, Franz-Josef; Avni, Yuval; Jones, Peter; Bornstein, Stefan R.:
Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes.
In: Proc Natl Acad Sci USA 400, S. 201708420.

Beyes, M.; Nause, N.; Bleyer, M.; Kaup, F.-J; Neumann, S.:
Description of post-implantation embryonic stages in European roe deer (Capreolus capreolus ) after embryonic diapause.
In: Anat. Histol. Embryol. 46 (6), S. 582–591.

Fechner, Kim; Schäfer, Jenny; Münster, Pia; Ternes, Kerstin; Döring, Susanne; Völkel, Inger et al.:


Barthel Y; Drews S; Fehr M; Moser I; Mätz-Rensing K; Baumgärtner W; Wohlsein P
Concurrent infection with Mycobacterium avium subsp. hominissuis and Giardia duodenalis in a chinchilla (Chinchilla lanigera f. dom.).
In: Berl Münch Tierärztl Wochenschr 129 (5/6), S. 242-246.

Bleyer, Martina; Curths, Christoph; Dahlmann, Franziska; Wichmann, Judy; Bauer, Natali; Moritz, Andreas et al.
Morphology and staining behavior of neutrophilic and eosinophilic granulocytes of the common marmoset (Callithrix jacchus).
In: Exp. Toxicol. Pathol. 68 (6), S. 335-343.

Bodemer W
In: Primate Biology 3, S. 47-50.

Denapaite D; Rieger M; Köndgen S; Brückner R; Ochigava I; Kappeler P et al.
Highly variable Streptococcus oralis are commen among viridans Streptococci isolated from primates.
In: mSphere 1 (2), S. e00041-15. HAAS,

Melanie; Kaup, Franz-Josef; Neumann, Stephan
Canine pyometra: a model for the analysis of serum CXCL8 in inflammation.
In: J. Vet. Med. Sci. (Journal of Veterinary Medical Science) 78 (3), S. 375-381.

Kalbitzer, Urs; Roos, Christian; Kopp, Gisela H.; Butynski, Thomas M.; Knauf, Sascha; Zinner, Dietmar; Fischer, Julia
Insights into the genetic foundation of aggression in Papio and the evolution of two length-polymorphisms in the promoter regions of serotonin-related genes (5-HTTLPR and MAOALPR) in Papionini.
In: BMC Evol Biol 16 (1), S. 121.

Klippert A; Bleyer M; Sauermann U; Neumann, B.; Kaul A; Daskalaki M et al.
Lymphocryptovirus-dependent occurrence of lymphoma in SIV-infected rhesus macaques with particular consideration to two uncommon cases of non-Hodgkin's lymphoma.
In: Primate Biology 3 (2), S. 65-75.

Knauf, Sascha; Raphael, Jane; Mitjà, Oriol; Lejora, Inyasi A.V; Chuma, Idrissa S.; Batamuzi, Emmanuel K. et al.
Isolation of Treponema DNA from Necrophagous Flies in a Natural Ecosystem.
In: EBioMedicine 11, S. 85-90.


Bodemer W
Immunodificiency viruses and prion disease.
In: Primate Biology 2, S. 65-69.

Deckmann, Klaus; Krasteva-Christ, Gabriela; Rafiq, Amir; Herden, Christine; Wichmann, Judy; Knauf, Sascha et al.
Cholinergic urethral brush cells are widespread throughout placental mammals.
In: Int. Immunopharmacol. 29 (1), S. 51-56.

Hennecke, Silvia; Beck, Julia; Bornemann-Kolatzki, Kirsten; Neumann, Stephan; Escobar, Hugo Murua; Nolte, Ingo et al.
Prevalence of the Prefoldin Subunit 5 Gene Deletion in Canine Mammary Tumors.
In: PLoS ONE 10 (7), S. e0131280.

Kaup F-J
From the working group "Experimental Pathology" to the department "Pathology Unit" - historical development in retrospect.
In: Primate Biology 2, S. 57-63.

Knauf, Sascha; Barnett, Ulrike; Maciej, Peter; Klapproth, Matthias; Ndao, Ibrahima; Frischmann, Sieghard et al.
High Prevalence of Antibodies against the Bacterium Treponema pallidum in Senegalese Guinea Baboons (Papio papio).
In: PLoS ONE 10 (11), S. e0143100.

Knauf, Sascha; Dahlmann, Franziska; Batamuzi, Emmanuel K.; Frischmann, Sieghard; Liu H
Validation of Serological Tests for the Detection of Antibodies Against Treponema pallidum in Nonhuman Primates.
In: PLoS Negl Trop Dis 9 (3), S. e0003637.

Marks, Michael; Mitjà, Oriol; Vestergaard, Lasse S.; Pillay, Allan; Knauf, Sascha; Chen, Cheng-Yen et al.
Challenges and key research questions for yaws eradication.
In: The Lancet Infectious Diseases 15 (10), S. 1220-1225.

Mätz-Rensing K; Hartmann T; Wendel T; Frick GM; Homolka S; Richter E et al.
Outbreak of tuberculosis in a colony of Rhesus monkeys (Macaca mulatta) after possible indirect contact with a human TB patient.
In: J Comp Pathol 153 (2-3), S. 81-91.

Mätz-Rensing K; Korte S
Basic physiology of Callithrix jacchus. Unter Mitarbeit von Mätz-Rensing K. In: Korte S. Schenk E. Weinbauer GF Bluemel J (Hg.):
The non-human primate in nonclinical drug development and safety assessment. 1st edition.

London: Elsevier, S. 115-133.

Nguyen, Nga; Fashing, Peter J.; Boyd, Derek A.; Barry, Tyler S.; Burke, Ryan J.; Goodale, C. Barret et al.
Fitness impacts of tapeworm parasitism on wild gelada monkeys at Guassa, Ethiopia.
In: Am. J. Primatol. 77 (5), S. 579-594.

Plotzki, Elena; Buerck, Lelia Wolf-van; Knauf, Yvonne; Becker, Tamara; Mätz-Rensing K; Schuster, Marion et al.
Virus safety of islet cell transplantation from transgenic pigs to marmosets.
In: Virus Res. 204, S. 95-102.

Siskos N; Lampe K; Kaup F-J; Mätz-Rensing K
Unique case of disseminated toxoplasmosis and concurrent hepatic capillariasis in a ring-tailed lemur: first case description.
In: Primate Biology 2 (1), S. 9-12.

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Curths, Christoph; Knauf, Sascha; Kaup F-J
Respiratory Animal Models in the Common Marmoset (Callithrix jacchus).
In: Veterinary Sciences 1 (1), S. 63-76.

Curths C; Wichmann J; Dunker S; Windt S; Hoymann HG; Lauenstein H-D et al.
Airway hyperresponsivenes in lipopolysaccharide-challenged common common marmosets (Callithrix jacchus).
In: Clin Sci 126 (2), S. 155-162.

Frenz, Meike; Kaup F-J; Neumann, Stephan
Serum vascular endothelial growth factor in dogs with haemangiosarcoma and haematoma.
In: Research in Veterinary Science 97 (2), S. 257-262.

Hoffmann, Rebecca; Braun, Armin; Knauf, Sascha; Kaup F-J; Bleyer M
Distribution of ciliated epithelial cells in the trachea of common marmosets (Callithrix jacchus).
In: J. Med. Primatol. (Journal of medical primatology) 43 (1), S. 55-58.

Knauf, Y.; Bostedt, H.; Failing, K.; Knauf S; Wehrend, A.
Gross Pathology and Endocrinology of Ovarian Cysts in Bitches.
In: Reprod Domest Anim (Reproduction in Domestic Animals) 49 (3), S. 463-468.

Lampe K; Rudnick JC; Bleyer M; Kaup F-J; Mätz-Rensing K
Fallbericht: Intravasculäres Lymphom bei einem Husarenaffen (Erythrocebus patas).
In: Tierärztliche Praxis Großtiere 42 (2), S. A7-A13.

Langer S; Jurczynski, K.; Gessler, A.; Kaup F-J; Bleyer M; Mätz-Rensing K
Ischiopagus Tripus Conjoined Twins in a Western Lowland Gorilla (Gorilla gorilla).
In: Journal of Comparative Pathology 150 (4), S. 469-473.

Radonić, Aleksandar; Metzger, Sonja; Dabrowski, Piotr Wojtek; Couacy-Hymann, Emmanuel; Schuenadel, Livia; Kurth, Andreas et al.
Fatal Monkeypox in Wild-Living Sooty Mangabey, Côte d'Ivoire, 2012.
In: Emerg. Infect. Dis. 20 (6), S. 1009-1011.

Schmitt, Anne; Mätz-Rensing K; Kaup F-J
Non-Human Primate Models of Orthopoxvirus Infections.
In: Veterinary Sciences 1 (1), S. 40-62.

Schmitt A; Lampe K; Bayrhof G; Kaup F-J; Mätz-Rensing K; Bleyer M
Letale Herpesvirus-simplex-Infektion bei zwei Weißbüschelaffen (Callithrix jacchus).
In: Tierärztliche Praxis Großtiere 42 (4), S. A7-A13.

Sopper, S.; Mätz-Rensing K; Muhl, T.; Heeney, J.; Stahl-Hennig, C.; Sauermann, U.
Host factors determine differential disease progression after infection with nef-deleted simian immunodeficiency virus.
In: J. Gen. Virol. 95 (PT10), S. 2273-2284.

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Beck, Julia; Hennecke, Silvia; Bornemann-Kolatzki, Kirsten; Urnovitz, Howard B.; Neumann, Stephan; Ströbel, Philipp et al.
Genome aberrations in canine mammary carcinomas and their detection in cell-free plasma DNA.
In: PLoS ONE 8 (9), S. e75485.

Coscolla M; Lewin A; Metzger S; Mätz-Rensing K; Calvignac-Spencer S; Nitsche A et al.
Novel Mycobacterium tuberculosis complex isolate from a wild chimpanzee.
In: Emerg Infect. Dis (Emerging infectious diseases) 19 (6), S. 969-976.

Gruber-Dujardin, E.; Jurczynski, K.; Kaup F-J; Mätz-Rensing K
Oncocytic adrenocortical carcinoma in a putty-nosed monkey (Cercopithecus nictitans) with hyperadrenocorticism.
In: J. Comp. Pathol. 149 (4), S. 509-513.

Harper K; Knauf S
Treponema pallidum infection in primates: clinical manifestations, epidemiology, and evolution of a stealthy pathogen.
Unter Mitarbeit von Knauf S.
In: Brinkworth JF, Pechenkina K (ed.) Primates, Pathogens, and Evolution: Series: Developments in Primatology: Progress and Prospects, Bd. 38, S. 189-219.

Hermes, Meike; Albrecht, Christina; Schrod A; Brameier, Markus; Walter, Lutz
Expression patterns of killer cell immunoglobulin-like receptors (KIR) of NK-cell and T-cell subsets in Old World monkeys.
In: PLoS ONE 8 (5), S. e64936.

Hoffmann R; Kaup F-J; Bleyer M
Atypical cilia in the respiratory tract of common marmosets (Callithrix jacchus) with and without concurrent lung disease.
In: Exp. Lung Res. 39 (9), S. 410-414.

Kirchner, S.; Mätz-Rensing K; Dorner, M. B.; Leendertz FH; Dorner, B. G.; Leendertz, S. A. J.
Necrotizing endometritis and isolation of an alpha-toxin producing strain of Clostridium septicum in a wild sooty mangabey from Côte d'Ivoire.
In: J. Med. Primatol. (Journal of medical primatology) 42 (4), S. 220-224.

Knauf S; Liu H; Harper KN
Treponemal infection in nonhuman primates as possible reservoir for human yaws.
In: Emerging infectious diseases 19 (12), S. 2058-2060.

Krasemann, Susanne; Mearini, Giulia; Krämer, Elisabeth; Wagenführ, Katja; Schulz-Schaeffer, Walter; Neumann, Melanie et al.
BSE-associated prion-amyloid cardiomyopathy in primates.
In: Emerging infectious diseases 19 (6), S. 985-988.

Montag, Judith; Schulz-Schaeffer, Walter; Schrod A; Hunsmann, Gerhard; Motzkus, Dirk
Asynchronous onset of clinical disease in BSE-infected macaques.
In: Emerging infectious diseases 19 (7), S. 1125-1127.

Prachar C; Kaup F-J; Neumann, S.
Soluble interleukin 2 receptor-alpha (sIL-2Rα) in the peripheral blood of dogs - Comparison of malignant neoplasia with other diseases.
In: Open J. Vet. Med 3 (2), S. 176-183.

Prachar C; Kaup F-J; Neumann S
Interleukin-1 beta (IL-1ß) in the peripheral blood of dogs as possible marker for the detection of early stages of inflammation.
In: Open J. Vet. Med. 3 (7), S. 302-308.

Sasseville, V. G.; Mankowski, J. L.; Baldessari, A.; Harbison, C.; Laing, S.; Kaliyaperumal, S. et al.
Meeting report: emerging respiratory viral infections and nonhuman primate case reports.
In: Vet. Pathol. 50 (6), S. 1145-1153.

Schaudien D; Flieshardt C; Moser I; Tipold A; Bleyer M; Hewicker-Trautwein M; Baumgärtner W
An unusual case of spinal cord restricted mycobacteriosis in a European mink.
In: Tierärztliche Praxis 41 (1), S. 63-66.

Seidel, Victoria; Hoffmann, Rebecca; Braun, Armin; Seehase, Sophie; Knauf, Sascha; Kaup F-J; Bleyer M
Distribution and morphology of Clara cells in common marmosets (Callithrix jacchus).
In: J. Med. Primatol. (Journal of medical primatology) 42 (2), S. 79-88.

West KA; Heymann EW; Mueller B; Gillespie TR
Patterns of infection with Cryptosporidium sp. and Giardia sp. in three species of free-ranging primates in the Peruvian Amazon.
In: Int J Primatol 34 (5), S. 939-945.

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Hanazawa, K.; Mueller, T.; Becker, T.; Heistermann, M.; Behr, R.; Sasaki, E.
Minimally invasive transabdominal collection of preimplantation enbryos from the common marmoset monkey (Callithrix jacchus).
In: Theriogenology 78 (4), S. 811-816.

Harper, K. N.; Fyumagwa, R.; Hoare, R.; Wambura, P.N; Coppenhaver, D.H; Sapolsky, R.M et al.
Treponema pallidum infection in the wild baboons of East Africa: Distribution and genetic characterization of the strains responsible.
In: PLoS ONE (/), S. e50882.

Jurczynski, K.; Gruber-Dujardin, E.; Widmer, D.;. Kaup, F-J; Mätz-Rensing K; Kaup F-J
Invasive aspergillosis in a Putty-nosed monkey (Cercopithecus nictitans) with adrenocortical Cushing's syndrome. // Invasive aspergillosis in a putty-nosed monkey (Cercopithecus nictitans) with adrenocortical Cushing's syndrome.
In: J. Med. Primatol 41 (41 // 3), S. 172-175.

Kaup F-J
Exotische Zoonosen am Beispiel von Primaten.
In: Vet. Med. Report (36), S. 10.

Kiesel, P.; Gibson, T.; Zischler, H.; Kiesel, Petra; Kues, Andreas; Kaup F-J et al.
Prion infected rhesus monkeys to study differential transcription of Alu DNA elements and editing Alu transcripts in neuronal cells and blood cells. // A comparative analysis to study editing of small noncoding BC200- and Alu transcripts in brain of prion-inoculated rhesus monkeys (M. Mulatta).
In: J. Med. Primatol 41 // 75 (7), S. 176-182 // 391-401.

Kiesel, P.; Kues, A.; Gibson, T. J.; Zischler, H.; Kiesel, Petra; Kues, Andreas et al.
A comparative analysis to study editing of small non coding BC200- and Alu transcripts in brain of prion inoculated rhesus monkeys (M. mulatta) // A comparative analysis to study editing of small noncoding BC200- and Alu transcripts in brain of prion-inoculated rhesus monkeys (M. Mulatta).
In: J. Toxicol. Environ. Health Part A 75 (75 // 7), S. 391-401.

Knauf S; Batamuzi, E. K.; Mlengeya, T.; Kilewo, M.; Lejora, I. A. V.; Nordhoff, M. et al.
Treponema Infection Associated With Genital Ulceration in Wild Baboons.
In: Vet. Pathol (49), S. 292-303.

Sasseville, V. G.; Mansfield, K. G.; Mankowski, J. L.; Tremblay, C.; Terio, K. A.; Mätz-Rensing K et al.
Meeting report: Spontaneous lesions and diseases in wild, captive-bred, and zoo-housed nonhuman primates and in nonhuman primate species used in drug safety studies.
In: Vet. Pathol. 49 (6), S. 1057-1069.

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