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The former Pathology Unit (until December 2017)

The former Pathology Unit (Head: Prof. Dr. Franz-Josef Kaup) was part of the Section Infection Research at the German Primate Center (DPZ). The former Pathology Unit conducted pathogenetic studies regarding spontaneous or experimentally induced infectious diseases in non-human primates using morphological methods.



Becker, Tamara; Pieper, Florian; Liebetanz, David; Bleyer, Martina; Schrod, Annette; Maetz-Rensing, Kerstin; Treue, Stefan
Suspect Guillain-Barré syndrome in a male rhesus macaque (Macaca mulatta).
In: Primate Biol. 4 (1), S. 27-32.

Bleyer, Martina; Kunze, Marius; Gruber-Dujardin, Eva; Mätz-Rensing, Kerstin
Spontaneous lung pathology in a captive common marmoset colony (Callithrix jacchus).
In: Primate Biol. 4 (1), S. 17-25.   

Cichon, Nicole; Lampe, Karen; Bremmer, Felix; Becker, Tamara; Mätz-Rensing, Kerstin (2017):
Unique case of granulomatous arteritis in a grey mouse lemur (Microcebus murinus) - first case description.
In: Primate Biol. 4 (1), S. 71-75.                              

Fechner, Kim; Mätz-Rensing, Kerstin; Lampe, Karen; Kaup, Franz-Josef; Czerny, Claus-Peter; Schäfer, Jenny
Detection of Mycobacterium avium subsp. paratuberculosis in non-human primates.
In: J Med Primatol 124, S. 290.    

Ferkau A; Raue K; Gruber-Dujardin E; Barkhoff M
Okuläre Onchozerkose bei einer Englischen Bulldogge mit positivem Leishmaniose-Antikörper-Titer.
In: Kleintierpraxis.              

Gruber-Dujardin, Eva; Bleyer, Martina; Mätz-Rensing, Kerstin
Morphological and immunohistochemical characterization of spontaneous endometriosis in rhesus macaques (Macaca mulatta).
In: Primate Biol. 4 (1), S. 77-91.

Hollmann, Anne K.; Bleyer, Martina; Tipold, Andrea; Neßler, Jasmin N.; Wemheuer, Wilhelm E.; Schütz, Ekkehard; Brenig, Bertram
A genome-wide association study reveals a locus for bilateral iridal hypopigmentation in Holstein Friesian cattle.
In: BMC Genet 18 (1), S. 589.

Lampe, Karen; Gottstein, B.; Becker, T.; Stahl-Hennig, C.; Kaup, F.-J; Mätz-Rensing, K.
Immunization of rhesus macaques with Echinococcus multilocularis recombinant 14-3-3 antigen leads to specific antibody response.
In: Parasitol Res.

Lampe, Karen; Rudnick, Jens-Christian; Leendertz, Fabian; Bleyer, Martina; Mätz-Rensing, Kerstin
Intravascular T-cell lymphoma in a patas monkey (Erythrocebus patas).
In: Primate Biol. 4 (1), S. 39-46.

Niehof, Monika; Hildebrandt, Tobias; Danov, Olga; Arndt, Kirsten; Koschmann, Jeannette; Dahlmann, Franziska et al.
RNA isolation from precision-cut lung slices (PCLS) from different species.
In: BMC Res Notes 10 (1), S. 118.

Pöhlmann, Stefan; Suntz, Michael; Akimkin, Valerij; Bleyer, Martina; Kaul, Artur
Herpes B virus replication and viral lesions in the liver of a cynomolgus macaque which died from severe disease with rapid onset.
In: J Med Primatol 13 (Suppl 1), S. 379.

Richard, Mathilde; Knauf, Sascha; Lawrence, Philip; Mather, Alison E.; Munster, Vincent J.; Müller, Marcel A. et al.
Factors determining human-to-human transmissibility of zoonotic pathogens via contact.
In: Current Opinion in Virology 22, S. 7-12.

Zinner, D.; Keller, C.; Butynski, T.M; Jong, Y.A de; Pozzi, L.; Knauf, S. et al.
Distribution of mitochondrial clades and morphotypes of baboons Papio spp. (Primates: Cercopithecidae) in eastern Africa.
In: Journal of East African Natural History.

Zmora, Pawel; Molau-Blazejewska, Paulina; Bertram, Stephanie; Walendy-Gnirß, Kerstin; Nehlmeier, Inga; Hartleib, Anika et al.
Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin.

Neumann, Stephan; Schuettler, Julia; Frenz, Meike; Kaup, Franz-Josef; Gessler, Frank (2017, Epub 10/16):
Investigation of serum Ki-67 as a biomarker in tumor-bearing dogs.
In: Research in Veterinary Science 110, S. 16–21.

Mietsch, Matthias; Sauermann, Ulrike; Mätz-Rensing, Kerstin; Klippert, Antonina; Daskalaki, Maria; Stolte-Leeb, Nicole; Stahl-Hennig, Christiane
Revisiting a quarter of a century of simian immunodeficiency virus (SIV)-associated cardiovascular diseases at the German Primate Center.
In: Primate Biol. 4 (1), S. 107–115.

Klegarth, Amy R.; Ezeonwu, Chigozie A.; Rompis, Aida; Lee, Benjamin P.Y.-H; Aggimarangsee, Nantiya; Chalise, Mukesh et al. 
Survey of Treponemal Infections in Free-Ranging and Captive Macaques, 1999–2012.
In: Emerg. Infect. Dis. 23 (5), S. 816–819.

Houinei, Wendy; Godornes, Charmie; Kapa, August; Knauf, Sascha; Mooring, Eric Q.; González-Beiras, Camila et al. 
Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea.
In: PLoS Negl Trop Dis 11 (5), S. e0004958.

Hoffmann, Constanze; Zimmermann, Fee; Biek, Roman; Kuehl, Hjalmar; Nowak, Kathrin; Mundry, Roger et al. 
Persistent anthrax as a major driver of wildlife mortality in a tropical rainforest.
In: Nature 548 (7665), S. 82–86.

Daskalaki, Maria; Neumann, Berit; Klippert, Antonina; Mätz-Rensing, Kerstin; Kaup, Franz-Josef; Stahl-Hennig, Christiane
Long-term efficient control of SIV infection in macaques is associated with an intact intestinal barrier.
In: J Med Primatol 46 (4), S. 144–148.

Kaup, Franz-Josef
Gorilla Pathology and Health Gorilla Pathology and Health. By John Cooper and Gordon Hull. Academic Press, London, UK. 2017. 666 pp. USA $140 (hardback); $125 (eBook).
In: Journal of Wildlife Diseases.

Mätz-Rensing, Kerstin; Yue, Constanze; Klenner, Jeanette; Ellerbrok, Heinz; Stahl-Hennig, Christiane:
Limited susceptibility of rhesus macaques to a cowpox virus isolated from a lethal outbreak among New World monkeys.
In: Primate Biol. 4 (2), S. 163–171.

Ludwig, Barbara; Ludwig, Stefan; Steffen, Anja; Knauf, Yvonne; Zimerman, Baruch; Heinke, Sophie; Lehmann, Susann; Schubert, Undine; Schmid, Janine; Bleyer, Martina; Schönmann, Uwe; Colton, Clark K.; Bonifacio, Ezio; Solimena, Michele; Reichel, Andreas; Schally, Andrew V.; Rotem, Avi; Barkai, Uriel; Grinberg-Rashi, Helena; Kaup, Franz-Josef; Avni, Yuval; Jones, Peter; Bornstein, Stefan R.:
Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes.
In: Proc Natl Acad Sci USA 400, S. 201708420.

Beyes, M.; Nause, N.; Bleyer, M.; Kaup, F.-J; Neumann, S.:
Description of post-implantation embryonic stages in European roe deer (Capreolus capreolus ) after embryonic diapause.
In: Anat. Histol. Embryol. 46 (6), S. 582–591.

Fechner, Kim; Schäfer, Jenny; Münster, Pia; Ternes, Kerstin; Döring, Susanne; Völkel, Inger et al.:

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Barthel Y; Drews S; Fehr M; Moser I; Mätz-Rensing K; Baumgärtner W; Wohlsein P
Concurrent infection with Mycobacterium avium subsp. hominissuis and Giardia duodenalis in a chinchilla (Chinchilla lanigera f. dom.).
In: Berl Münch Tierärztl Wochenschr 129 (5/6), S. 242-246.

Bleyer, Martina; Curths, Christoph; Dahlmann, Franziska; Wichmann, Judy; Bauer, Natali; Moritz, Andreas et al.
Morphology and staining behavior of neutrophilic and eosinophilic granulocytes of the common marmoset (Callithrix jacchus).
In: Exp. Toxicol. Pathol. 68 (6), S. 335-343.

Bodemer W
In: Primate Biology 3, S. 47-50.

Denapaite D; Rieger M; Köndgen S; Brückner R; Ochigava I; Kappeler P et al.
Highly variable Streptococcus oralis are commen among viridans Streptococci isolated from primates.
In: mSphere 1 (2), S. e00041-15. HAAS,

Melanie; Kaup, Franz-Josef; Neumann, Stephan
Canine pyometra: a model for the analysis of serum CXCL8 in inflammation.
In: J. Vet. Med. Sci. (Journal of Veterinary Medical Science) 78 (3), S. 375-381.

Kalbitzer, Urs; Roos, Christian; Kopp, Gisela H.; Butynski, Thomas M.; Knauf, Sascha; Zinner, Dietmar; Fischer, Julia
Insights into the genetic foundation of aggression in Papio and the evolution of two length-polymorphisms in the promoter regions of serotonin-related genes (5-HTTLPR and MAOALPR) in Papionini.
In: BMC Evol Biol 16 (1), S. 121.

Klippert A; Bleyer M; Sauermann U; Neumann, B.; Kaul A; Daskalaki M et al.
Lymphocryptovirus-dependent occurrence of lymphoma in SIV-infected rhesus macaques with particular consideration to two uncommon cases of non-Hodgkin's lymphoma.
In: Primate Biology 3 (2), S. 65-75.

Knauf, Sascha; Raphael, Jane; Mitjà, Oriol; Lejora, Inyasi A.V; Chuma, Idrissa S.; Batamuzi, Emmanuel K. et al.
Isolation of Treponema DNA from Necrophagous Flies in a Natural Ecosystem.
In: EBioMedicine 11, S. 85-90.

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Bodemer W
Immunodificiency viruses and prion disease.
In: Primate Biology 2, S. 65-69.

Deckmann, Klaus; Krasteva-Christ, Gabriela; Rafiq, Amir; Herden, Christine; Wichmann, Judy; Knauf, Sascha et al.
Cholinergic urethral brush cells are widespread throughout placental mammals.
In: Int. Immunopharmacol. 29 (1), S. 51-56.

Hennecke, Silvia; Beck, Julia; Bornemann-Kolatzki, Kirsten; Neumann, Stephan; Escobar, Hugo Murua; Nolte, Ingo et al.
Prevalence of the Prefoldin Subunit 5 Gene Deletion in Canine Mammary Tumors.
In: PLoS ONE 10 (7), S. e0131280.

Kaup F-J
From the working group "Experimental Pathology" to the department "Pathology Unit" - historical development in retrospect.
In: Primate Biology 2, S. 57-63.

Knauf, Sascha; Barnett, Ulrike; Maciej, Peter; Klapproth, Matthias; Ndao, Ibrahima; Frischmann, Sieghard et al.
High Prevalence of Antibodies against the Bacterium Treponema pallidum in Senegalese Guinea Baboons (Papio papio).
In: PLoS ONE 10 (11), S. e0143100.

Knauf, Sascha; Dahlmann, Franziska; Batamuzi, Emmanuel K.; Frischmann, Sieghard; Liu H
Validation of Serological Tests for the Detection of Antibodies Against Treponema pallidum in Nonhuman Primates.
In: PLoS Negl Trop Dis 9 (3), S. e0003637.

Marks, Michael; Mitjà, Oriol; Vestergaard, Lasse S.; Pillay, Allan; Knauf, Sascha; Chen, Cheng-Yen et al.
Challenges and key research questions for yaws eradication.
In: The Lancet Infectious Diseases 15 (10), S. 1220-1225.

Mätz-Rensing K; Hartmann T; Wendel T; Frick GM; Homolka S; Richter E et al.
Outbreak of tuberculosis in a colony of Rhesus monkeys (Macaca mulatta) after possible indirect contact with a human TB patient.
In: J Comp Pathol 153 (2-3), S. 81-91.

Mätz-Rensing K; Korte S
Basic physiology of Callithrix jacchus. Unter Mitarbeit von Mätz-Rensing K. In: Korte S. Schenk E. Weinbauer GF Bluemel J (Hg.):
The non-human primate in nonclinical drug development and safety assessment. 1st edition.

London: Elsevier, S. 115-133.

Nguyen, Nga; Fashing, Peter J.; Boyd, Derek A.; Barry, Tyler S.; Burke, Ryan J.; Goodale, C. Barret et al.
Fitness impacts of tapeworm parasitism on wild gelada monkeys at Guassa, Ethiopia.
In: Am. J. Primatol. 77 (5), S. 579-594.

Plotzki, Elena; Buerck, Lelia Wolf-van; Knauf, Yvonne; Becker, Tamara; Mätz-Rensing K; Schuster, Marion et al.
Virus safety of islet cell transplantation from transgenic pigs to marmosets.
In: Virus Res. 204, S. 95-102.

Siskos N; Lampe K; Kaup F-J; Mätz-Rensing K
Unique case of disseminated toxoplasmosis and concurrent hepatic capillariasis in a ring-tailed lemur: first case description.
In: Primate Biology 2 (1), S. 9-12.

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Curths, Christoph; Knauf, Sascha; Kaup F-J
Respiratory Animal Models in the Common Marmoset (Callithrix jacchus).
In: Veterinary Sciences 1 (1), S. 63-76.

Curths C; Wichmann J; Dunker S; Windt S; Hoymann HG; Lauenstein H-D et al.
Airway hyperresponsivenes in lipopolysaccharide-challenged common common marmosets (Callithrix jacchus).
In: Clin Sci 126 (2), S. 155-162.

Frenz, Meike; Kaup F-J; Neumann, Stephan
Serum vascular endothelial growth factor in dogs with haemangiosarcoma and haematoma.
In: Research in Veterinary Science 97 (2), S. 257-262.

Hoffmann, Rebecca; Braun, Armin; Knauf, Sascha; Kaup F-J; Bleyer M
Distribution of ciliated epithelial cells in the trachea of common marmosets (Callithrix jacchus).
In: J. Med. Primatol. (Journal of medical primatology) 43 (1), S. 55-58.

Knauf, Y.; Bostedt, H.; Failing, K.; Knauf S; Wehrend, A.
Gross Pathology and Endocrinology of Ovarian Cysts in Bitches.
In: Reprod Domest Anim (Reproduction in Domestic Animals) 49 (3), S. 463-468.

Lampe K; Rudnick JC; Bleyer M; Kaup F-J; Mätz-Rensing K
Fallbericht: Intravasculäres Lymphom bei einem Husarenaffen (Erythrocebus patas).
In: Tierärztliche Praxis Großtiere 42 (2), S. A7-A13.

Langer S; Jurczynski, K.; Gessler, A.; Kaup F-J; Bleyer M; Mätz-Rensing K
Ischiopagus Tripus Conjoined Twins in a Western Lowland Gorilla (Gorilla gorilla).
In: Journal of Comparative Pathology 150 (4), S. 469-473.

Radonić, Aleksandar; Metzger, Sonja; Dabrowski, Piotr Wojtek; Couacy-Hymann, Emmanuel; Schuenadel, Livia; Kurth, Andreas et al.
Fatal Monkeypox in Wild-Living Sooty Mangabey, Côte d'Ivoire, 2012.
In: Emerg. Infect. Dis. 20 (6), S. 1009-1011.

Schmitt, Anne; Mätz-Rensing K; Kaup F-J
Non-Human Primate Models of Orthopoxvirus Infections.
In: Veterinary Sciences 1 (1), S. 40-62.

Schmitt A; Lampe K; Bayrhof G; Kaup F-J; Mätz-Rensing K; Bleyer M
Letale Herpesvirus-simplex-Infektion bei zwei Weißbüschelaffen (Callithrix jacchus).
In: Tierärztliche Praxis Großtiere 42 (4), S. A7-A13.

Sopper, S.; Mätz-Rensing K; Muhl, T.; Heeney, J.; Stahl-Hennig, C.; Sauermann, U.
Host factors determine differential disease progression after infection with nef-deleted simian immunodeficiency virus.
In: J. Gen. Virol. 95 (PT10), S. 2273-2284.

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Beck, Julia; Hennecke, Silvia; Bornemann-Kolatzki, Kirsten; Urnovitz, Howard B.; Neumann, Stephan; Ströbel, Philipp et al.
Genome aberrations in canine mammary carcinomas and their detection in cell-free plasma DNA.
In: PLoS ONE 8 (9), S. e75485.

Coscolla M; Lewin A; Metzger S; Mätz-Rensing K; Calvignac-Spencer S; Nitsche A et al.
Novel Mycobacterium tuberculosis complex isolate from a wild chimpanzee.
In: Emerg Infect. Dis (Emerging infectious diseases) 19 (6), S. 969-976.

Gruber-Dujardin, E.; Jurczynski, K.; Kaup F-J; Mätz-Rensing K
Oncocytic adrenocortical carcinoma in a putty-nosed monkey (Cercopithecus nictitans) with hyperadrenocorticism.
In: J. Comp. Pathol. 149 (4), S. 509-513.

Harper K; Knauf S
Treponema pallidum infection in primates: clinical manifestations, epidemiology, and evolution of a stealthy pathogen.
Unter Mitarbeit von Knauf S.
In: Brinkworth JF, Pechenkina K (ed.) Primates, Pathogens, and Evolution: Series: Developments in Primatology: Progress and Prospects, Bd. 38, S. 189-219.

Hermes, Meike; Albrecht, Christina; Schrod A; Brameier, Markus; Walter, Lutz
Expression patterns of killer cell immunoglobulin-like receptors (KIR) of NK-cell and T-cell subsets in Old World monkeys.
In: PLoS ONE 8 (5), S. e64936.

Hoffmann R; Kaup F-J; Bleyer M
Atypical cilia in the respiratory tract of common marmosets (Callithrix jacchus) with and without concurrent lung disease.
In: Exp. Lung Res. 39 (9), S. 410-414.

Kirchner, S.; Mätz-Rensing K; Dorner, M. B.; Leendertz FH; Dorner, B. G.; Leendertz, S. A. J.
Necrotizing endometritis and isolation of an alpha-toxin producing strain of Clostridium septicum in a wild sooty mangabey from Côte d'Ivoire.
In: J. Med. Primatol. (Journal of medical primatology) 42 (4), S. 220-224.

Knauf S; Liu H; Harper KN
Treponemal infection in nonhuman primates as possible reservoir for human yaws.
In: Emerging infectious diseases 19 (12), S. 2058-2060.

Krasemann, Susanne; Mearini, Giulia; Krämer, Elisabeth; Wagenführ, Katja; Schulz-Schaeffer, Walter; Neumann, Melanie et al.
BSE-associated prion-amyloid cardiomyopathy in primates.
In: Emerging infectious diseases 19 (6), S. 985-988.

Montag, Judith; Schulz-Schaeffer, Walter; Schrod A; Hunsmann, Gerhard; Motzkus, Dirk
Asynchronous onset of clinical disease in BSE-infected macaques.
In: Emerging infectious diseases 19 (7), S. 1125-1127.

Prachar C; Kaup F-J; Neumann, S.
Soluble interleukin 2 receptor-alpha (sIL-2Rα) in the peripheral blood of dogs - Comparison of malignant neoplasia with other diseases.
In: Open J. Vet. Med 3 (2), S. 176-183.

Prachar C; Kaup F-J; Neumann S
Interleukin-1 beta (IL-1ß) in the peripheral blood of dogs as possible marker for the detection of early stages of inflammation.
In: Open J. Vet. Med. 3 (7), S. 302-308.

Sasseville, V. G.; Mankowski, J. L.; Baldessari, A.; Harbison, C.; Laing, S.; Kaliyaperumal, S. et al.
Meeting report: emerging respiratory viral infections and nonhuman primate case reports.
In: Vet. Pathol. 50 (6), S. 1145-1153.

Schaudien D; Flieshardt C; Moser I; Tipold A; Bleyer M; Hewicker-Trautwein M; Baumgärtner W
An unusual case of spinal cord restricted mycobacteriosis in a European mink.
In: Tierärztliche Praxis 41 (1), S. 63-66.

Seidel, Victoria; Hoffmann, Rebecca; Braun, Armin; Seehase, Sophie; Knauf, Sascha; Kaup F-J; Bleyer M
Distribution and morphology of Clara cells in common marmosets (Callithrix jacchus).
In: J. Med. Primatol. (Journal of medical primatology) 42 (2), S. 79-88.

West KA; Heymann EW; Mueller B; Gillespie TR
Patterns of infection with Cryptosporidium sp. and Giardia sp. in three species of free-ranging primates in the Peruvian Amazon.
In: Int J Primatol 34 (5), S. 939-945.

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Hanazawa, K.; Mueller, T.; Becker, T.; Heistermann, M.; Behr, R.; Sasaki, E.
Minimally invasive transabdominal collection of preimplantation enbryos from the common marmoset monkey (Callithrix jacchus).
In: Theriogenology 78 (4), S. 811-816.

Harper, K. N.; Fyumagwa, R.; Hoare, R.; Wambura, P.N; Coppenhaver, D.H; Sapolsky, R.M et al.
Treponema pallidum infection in the wild baboons of East Africa: Distribution and genetic characterization of the strains responsible.
In: PLoS ONE (/), S. e50882.

Jurczynski, K.; Gruber-Dujardin, E.; Widmer, D.;. Kaup, F-J; Mätz-Rensing K; Kaup F-J
Invasive aspergillosis in a Putty-nosed monkey (Cercopithecus nictitans) with adrenocortical Cushing's syndrome. // Invasive aspergillosis in a putty-nosed monkey (Cercopithecus nictitans) with adrenocortical Cushing's syndrome.
In: J. Med. Primatol 41 (41 // 3), S. 172-175.

Kaup F-J
Exotische Zoonosen am Beispiel von Primaten.
In: Vet. Med. Report (36), S. 10.

Kiesel, P.; Gibson, T.; Zischler, H.; Kiesel, Petra; Kues, Andreas; Kaup F-J et al.
Prion infected rhesus monkeys to study differential transcription of Alu DNA elements and editing Alu transcripts in neuronal cells and blood cells. // A comparative analysis to study editing of small noncoding BC200- and Alu transcripts in brain of prion-inoculated rhesus monkeys (M. Mulatta).
In: J. Med. Primatol 41 // 75 (7), S. 176-182 // 391-401.

Kiesel, P.; Kues, A.; Gibson, T. J.; Zischler, H.; Kiesel, Petra; Kues, Andreas et al.
A comparative analysis to study editing of small non coding BC200- and Alu transcripts in brain of prion inoculated rhesus monkeys (M. mulatta) // A comparative analysis to study editing of small noncoding BC200- and Alu transcripts in brain of prion-inoculated rhesus monkeys (M. Mulatta).
In: J. Toxicol. Environ. Health Part A 75 (75 // 7), S. 391-401.

Knauf S; Batamuzi, E. K.; Mlengeya, T.; Kilewo, M.; Lejora, I. A. V.; Nordhoff, M. et al.
Treponema Infection Associated With Genital Ulceration in Wild Baboons.
In: Vet. Pathol (49), S. 292-303.

Sasseville, V. G.; Mansfield, K. G.; Mankowski, J. L.; Tremblay, C.; Terio, K. A.; Mätz-Rensing K et al.
Meeting report: Spontaneous lesions and diseases in wild, captive-bred, and zoo-housed nonhuman primates and in nonhuman primate species used in drug safety studies.
In: Vet. Pathol. 49 (6), S. 1057-1069.

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