The former Pathology Unit (until December 2017)
The former Pathology Unit (Head: Prof. Dr. Franz-Josef Kaup) was part of the Section Infection Research at the German Primate Center (DPZ). The former Pathology Unit conducted pathogenetic studies regarding spontaneous or experimentally induced infectious diseases in non-human primates using morphological methods.
Recently, the common marmoset (Callithrix jacchus) has increasingly attracted attention as a potentially useful animal model in the field of respiratory research. Detailed knowledge on functional morphology and cellular composition of thr respiratory epithelium is essential for suitability assessment of of the common marmoset as an animal model for chronic respiratory diseases. The working group 'Anatomy/Pathology' performs investigations on the morphology of the respiratory tract in common marmosets (Callithrix jacchus) with the objective to characterize the marmoset model of human chronic respiratory diseases (COPD and asthma) on a structural basis.
The research focus currently lies on the qualitative and quantitative evaluation of a subacute and chronic asthma model in the common marmoset. Especially the composition of the secretory cell population and the distribution of mast cell in the conducting airways of marmosets are investigated using stereological methods.