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Mitarbeiter

PD Dr. Michael Winkler

Gruppenleiter

Infektionsbiologie

+49 551 3851-383

+49 551 3851-269

MWinkler(at)dpz.eu

Kellnerweg 4
37077 Göttingen

Gesellschaft für Virologie, American Society for Microbiology

2013

Bogdanow B, Weisbach H, von Einem J, Straschewski S, Voigt S, Winkler M, Hagemeier C, Wiebusch L (2013) Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state. PNAS, 110, 17510-17515

Bertram S, Dijkman R, Habjan M, Heurich A, Gierer S, Glowacka I, Welsch K, Winkler M, Schneider H, Hofmann-Winkler H, Thiel V, Pöhlmann S (2013) TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium. J. Virol., 87, 6150-6160

Gierer S, Bertram S, Kaup F, Wrensch F, Heurich A, Krämer-Kühl A, Welsch K, Winkler M, Meyer B, Drosten C, Dittmer U, von Hahn T, Simmons G, Hofmann H, Pöhlmann S (2013) The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies. J. Virol., 87, 5502-11

2012

Sinigalia E, Alvisi G, Segré CV, Mercorelli B, Muratore G, Winkler M, Hsiao HH, Urlaub H, Ripalti A, Chiocca S, Palù G, Loregian A (2012) The human cytomegalovirus DNA polymerase processivity factor UL44 is modified by SUMO in a DNA-dependent manner. PLoS One, 7, e49630

Winkler M, Bertram S, Gnirß K, Nehlmeier I, Gawanbacht A, Kirchhoff F, Ehrhardt C, Ludwig S, Kiene M, Moldenhauer AS, Goedecke U, Karsten CB, Kühl A, Pöhlmann S (2012) Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells. PLoS One, 7, e43337

Müller D, Schreiner S, Schmid M, Groitl P, Winkler M, Dobner T (2012) Functional cooperation between human adenovirus type 5 early region 4, open reading frame 6 protein, and cellular homeobox protein HoxB7. J. Virol., 86, 8296-8308

2010

Fertey J, Ammermann I, Winkler M, Stöger R, Iftner T, Stubenrauch F (2010) Interaction of the papillomavirus E8--E2C protein with the cellular CHD6 protein contributes to transcriptional repression. J. Virol., 84, 9505-9515

Straschewski S, Warmer M, Frascaroli G, Hohenberg H, Mertens T, Winkler M (2010) Human Cytomegaloviruses Expressing Yellow Fluorescent Fusion Proteins - Characterization and Use in Antiviral Screening. PLoS ONE, 5, e9174

Kuenzel S, Till A, Winkler M, Häsler R, Lipinski S, Jung S, Grötzinger J, Fickenscher H, Schreiber S, Rosenstiel P (2010): The Nucleotide Oligomerization Binding Domain-Like Receptor NLRC5 Is Involved in IFN-Dependent Antiviral Immune Responses. J. Immunol., 184, 1990 -2000

2009

Liu Z, Winkler M, Biegalke B (2009) Human cytomegalovirus: host immune modulation by the viral US3 gene. Int J Biochem Cell Biol., 41, 503-506

2008

Dal Pozzo F, Andrei G, Daelemans D, Winkler M, Piette J, De Clercq E, Snoeck R (2008) Fluorescence-based antiviral assay for the evaluation of compounds against vaccinia virus, varicella zoster virus and human cytomegalovirus. J Virol Methods, 151, 66-73

2006

Reinhardt B, Winkler M, Schaarschmidt P, Pretsch R, Lüske A, Vaida B, Schmid-Kotsas A, Michel D, Walther P, Bachem M, Mertens T (2006) HCMV-induced reduction of extracellular matrix proteins in vascular smooth muscle cell cultures: a pathomechanism in vasculopathies? J. Gen. Virol., 87, 2849-2858

2005

Oswald F, Winkler M, Cao Y, Astrahantseff K, Soizic Bourteele S, Knöchel W, Borggrefe T (2005) RBP-Jκ-SHARP recruit corepressors CtIP-CtBP to silence Notch target genes. Mol. Cell. Biol., 25, 10379-10390

Schierling K, Buser C, Mertens T, Winkler M (2005) The Human Cytomegalovirus tegument protein pUL35 is important for viral replication and particle formation. J. Virol, 79, 3084-3096

2004

Schierling K, Stamminger T, Mertens T, Winkler M (2004) The Human Cytomegalovirus tegument proteins ppUL82(pp71) and ppUL35 interact and co-operatively activate the major immediate-early enhancer. J Virol, 78, 9512-9523

2003

Shen C, Buck AK, Liu X, Winkler M, Reske SN (2003) Gene silencing by adenovirus-delivered siRNA. FEBS Lett, 539, 111-114

Lischka P, Sorg G, Kann M, Winkler M, Stamminger T (2003) A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. J Virol. 77, 3734-3748

Winkler M (2003) Interactions and Functions of Human Cytomegalovirus Tegument Proteins. Monogr Virol., 24, 113–121

2002

Stamminger T, Gstaiger M, Weinzierl K, Lorz K, Winkler M, Schaffner W (2002) The open reading frame UL26 of human cytomegalovirus encodes a novel tegumant protein that contains a strong transcriptional activation domain. J Virol, 76, 4836-4847

2001

Fernandez LA, Winkler M, Grosschedl R (2001) Matrix attachment region-dependent function of the immunoglobulin m enhancer involves histone acetylation at a distance without changes in enhancer occupancy. Mol Cell Biol, 21, 196-208

2000

Winkler M, aus dem Siepen T, Stamminger T (2000) Functional interaction between pleiotropic transactivator pUL69 of human cytomegalovirus and the human homolog of yeast chromatin regulatory protein SPT6. J Virol, 74, 8053-8064

1998

Fernandez LA, Winkler M, Forrester W, Jenuwein T, Grosschedl R (1998) Nuclear matrix attachment regions confer long-range function upon the immunoglobulin μ enhancer. Cold Spring Harb Symp Quant Biol, 63, 515-524

1996

Winkler M, Stamminger T (1996) A specific subform of the human cytomegalovirus transactivator protein pUL69 is contained within the tegument of virus particles. J Virol, 70, 8984-8987

1995

Winkler M, Schmolke S, Plachter B, Stamminger T (1995) The pUL69 Protein of Human Cytomegalovirus (HCMV), a Homologue of the Herpes Simplex Virus ICP27, is Contained within the Tegument of Virions and Activates the Major Immediate-early Enhancer of HCMV in Synergy with the Tegument Protein pp71 (ppUL82). Scand J Infect Dis Suppl, 99, 8-9

1994

Winkler M, Rice SA, Stamminger T (1994) UL69 of human cytomegalovirus, an open reading frame with homology to ICP27 of herpes simplex virus, encodes a transactivator of gene expression. J Virol, 68, 3943-3954

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