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Staff

Dr. Michael Heide

Team Leader/Group Leader

Degenerative Diseases

+49 551 3851-323

MHeide(at)dpz.eu

Kellnerweg 4
37077 Göttingen

Primate neocortex development and evolution, brain organoids, neural stem cells, primate-specific genes

Heide, M.* and Huttner W.B.* (2021). Human-specific genes, cortical progenitor cells, and microcephaly. Cells 10, 1209-1215. *joint corresponding authors

Heide, M.*, Haffner, C., Murayama, A., Kurotaki, Y., Shinohara, H., Okano H., Sasaki, E. and Huttner W.B.* (2020). Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset. Science 369, 546-550. *joint corresponding authors

Fischer, J.*, Heide, M.*# and Huttner, W.B.# (2019). Genetic modification of brain organoids. Front Cell Neurosci 13, 558. *joint first authors, #joint corresponding authors

Kanton, S., Boyle, M.J., He, Z., Santel, M., Weigert, A., Calleja, F.S., Guijarro, P., Sidow, L., Fleck, J.S., Han, D., Qian, Z., Heide, M., Huttner, W.B., Khaitovich, P., Pääbo, S., Treutlein, B. and Camp, J.G. (2019). Organoid single-cell genomic atlas uncovers human-specific features of brain development. Nature 574, 418-422.

Heide, M., Huttner, W.B. and Mora-Bermudez, F. (2018). Brain organoids as models to study human neocortex development and evolution. Curr Opin Cell Biol 55, 8-16.

Florio, M.*, Heide, M.*, Pinson A., Brandl, H., Albert, M., Winkler, S., Wimberger, P., Huttner, W.B. and Hiller, M. (2018). Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex. eLife 7:e32332. *joint first authors

Heide, M., Long, K.R. and Huttner, W.B. (2017). Novel gene function and regulation in neocortex expansion. Curr Opin Cell Biol 49, 22-30.

Boothe, T., Hilbert, L., Heide, M., Berninger, L., Huttner, W.B., Zaburdaev, V., Vastenhouw, N.L., Myers, E.W., Drechsel, D.N. and Rink, J.C. (2017) A tunable refractive index matching medium for live imaging cells, tissues and model organisms. eLife 6:e27240.

Miquelajáuregui, A., Sandoval-Schaefer, T., Martínez-Armenta, M., Pérez-Martínez, L., Cárabez, A., Zhao, Y., Heide, M., Alvarez-Bolado, G., Varela-Echavarría, A. (2015). LIM homeobox protein 5 (Lhx5) is essential for mamillary body development. Front Neuroanat 9, 136.

Heide, M. *, Zhang, Y., Zhou, X., Zhao, T., Miquelajáuregui, A., Varela-Echavarría, A., Alvarez-Bolado, G. (2015). Lhx5 controls mamillary differentiation in the developing hypothalamus of the mouse. Front Neuroanat 9, 113. *joint corresponding authors

Haddad-Tóvolli, R., Heide, M., Zhou, X., Blaess, S., Alvarez-Bolado, G. (2012). Mouse thalamic differentiation: gli-dependent pattern and gli-independent prepattern. Front Neurosci 6, 27.

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