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Planned movements and spontaneous reactions are processed differently in the brain

A rhesus monkeys study highlights the role of the brain regions involved in the planning of movements
On the starting line the runners can plan their first steps but when one of the participants falls, they must all react spontaneously. Photo: Julien Crosnier /KMSP / DPPI
Signals on the monitor indicate which movements are to be performed. At first, the animal should look at the red circle in the middle (fixation point). A green circle indicates a power grip and a white circle a precision grip. However, the grips can only be performed when the red light disappears. This happens either immediately or after a waiting period of 0 to 1300 milliseconds. Image: Benjamin Dann
Signals on the monitor indicate which movements are to be performed. At first, the animal should look at the red circle in the middle (fixation point). A green circle indicates a power grip and a white circle a precision grip. However, the grips can only be performed when the red light disappears. This happens either immediately or after a waiting period of 0 to 1300 milliseconds. Image: Benjamin Dann
This figure shows the neuronal population activity in the brain when a power grip is executed. During the planning phase the activity patterns differ, depending on the waiting time (light blue: long waiting time, dark blue: short waiting time), during the execution of the movement there are no significant differences. Image: Benjamin Dann. CC-BY-NC-ND 4.0 International license.
This figure shows the neuronal population activity in the brain when a power grip is executed. During the planning phase the activity patterns differ, depending on the waiting time (light blue: long waiting time, dark blue: short waiting time), during the execution of the movement there are no significant differences. Image: Benjamin Dann. CC-BY-NC-ND 4.0 International license.
Dr. Benjamin Dann is a scientist in the Neurobiology Laboratory at the German Primate Center. Photo: Karin Tilch
Dr. Benjamin Dann is a scientist in the Neurobiology Laboratory at the German Primate Center. Photo: Karin Tilch
Dr. Jonathan A. Michaels was a scientist in the Neurobiology Laboratory at the German Primate Center until 2017 and is currently working as a scientist in the Neural Prosthetics Systems Lab of the University of Stanford in California. Photo: Karin Tilch
Dr. Jonathan A. Michaels was a scientist in the Neurobiology Laboratory at the German Primate Center until 2017 and is currently working as a scientist in the Neural Prosthetics Systems Lab of the University of Stanford in California. Photo: Karin Tilch

The runners are lined up at the starting line, patiently awaiting the start signal for the 1000-meter race. In the second turn a runner falls in front of the one next to him. He dodges his falling neighbor and continues to sprint towards the finish line. Whilst awaiting the start signal, the runner had time to plan his first steps, whilst dodging, he had to react immediately. Until now, the difference between the brain activity of planned and spontaneous movements have been unknown. Scientists from the German Primate Center – Leibniz Institute for Primate Research (DPZ) have been able to show in their recently published study of two rhesus monkeys that planned and spontaneous gripping movements have the same brain activity during the movement but that the preceded brain activity differs. This helps us to understand what happens in the brain when we plan a movement and not execute it immediately – an important finding that could be helpful for clinical rehabilitation measures.

The neuroscientists Benjamin Dann and Jonathan Michaels of the German Primate Center have trained two rhesus monkeys to perform a gripping movement when a certain signal appears. Depending on whether a green or white circle appeared on a screen, the animals had to make a power grip with the whole hand or a precision grip with two fingers. However, they were only allowed to execute the movement when a red circle disappeared from the monitor. In the brain, the first decision was to choose the type of movement (power or precision grip) and then wait for the signal to indicate the actual start of the movement. This waiting period varied from 0 to 1300 milliseconds.

In order to systematically study the interplay of planning and movement in the brain, the scientists measured the activity of populations of neurons responsible for generating and executing grasping movements in two different brain regions. Depending on the length of the waiting period before the animals were allowed to perform the indicated movement, the original activity of the neuronal populations of both areas changed to a state of planning. "Our results show that planning a movement not only retains the brain activity necessary to perform a movement, but it also shows that a new state of activity for movements from short-term memory exists," says Benjamin Dann, one of the two lead authors of the study. These findings could be helpful for developing rehabilitation measures for patients who, for example after a stroke or a tumor operation, have difficulties with planning and initializing of movements. “If we understand how exactly our brain works when planning a movement, we could treat motoric handicaps more specific in future,” says Benjamin Dann.

Original publication

Jonathan A Michaels, Benjamin Dann, Rijk W Intveld and Hansjörg Scherberger: Neural dynamics of variable grasp movement preparation in the macaque fronto-parietal network. Journal of Neuroscience 24 May 2018, 2557-17; DOI: https://doi.org/10.1523/JNEUROSCI.2557-17.2018